Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans

Darren P Casey; Michael J Joyner

doi:10.1152/japplphysiol.00331.2009

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Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans

Journal article

Open access

Peer reviewed

Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans

Darren P Casey and Michael J Joyner

Journal of applied physiology (1985), Vol.107(2), pp.429-437

08/2009

DOI: 10.1152/japplphysiol.00331.2009

PMCID: PMC2846031

PMID: 19520838

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Abstract

We evaluated the contribution of changes in systemic arterial pressure and local vasodilation to blood flow restoration in contracting human muscles during acute hypoperfusion. Healthy subjects (n=10) performed rhythmic forearm exercise (10% and 20% of maximum) while a balloon in the brachial artery located above the elbow was inflated. Each trial included 3 min of rest, exercise, exercise with balloon inflation, and exercise after balloon deflation. Forearm blood flow (FBF) was measured using Doppler ultrasound. Blood pressure on both sides of the balloon was measured using a brachial artery catheter (distal pressure), and Finometer for proximal (systemic) arterial pressure. Balloon inflation during exercise reduced distal arterial pressure, and FBF fell 37-41%. There was also a surprising acute increase in forearm vascular resistance (distal pressure/FBF). This was followed by recovery of distal arterial pressure and forearm vasodilation that caused a marked (approximately 75%) restoration of flow that was not associated with significant changes in systemic arterial pressure. During validation trials (n=6) at rest and with exercise both balloon and brachial artery diameters were stable when the balloon was inflated. Our findings indicate that at these exercise intensities 1) the restoration of FBF during exercise with hypoperfusion relied primarily on local dilator responses in conjunction with restoration of distal perfusion pressure likely as a result of increased collateral flow around the elbow, and 2) a loss of pulsatile flow and elastic recoil in the forearm may have contributed to the acute increase in vascular resistance seen at the onset of hypoperfusion.

Blood Pressure

Heart Rate

Reproducibility of Results

Vascular Resistance

Pulsatile Flow

Humans

Collateral Circulation

Male

Laser-Doppler Flowmetry

Regional Blood Flow

Vasodilation

Brachial Artery - diagnostic imaging

Exercise

Forearm

Muscle Contraction

Time Factors

Hyperemia - physiopathology

Ultrasonography

Adult

Brachial Artery - physiopathology

Muscle, Skeletal - blood supply

Details

Title: Subtitle: Skeletal muscle blood flow responses to hypoperfusion at rest and during rhythmic exercise in humans
Creators: Darren P Casey - Department of Anesthesiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. casey.darren@mayo.edu
Michael J Joyner
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.107(2), pp.429-437
DOI: 10.1152/japplphysiol.00331.2009
PMID: 19520838
PMCID: PMC2846031
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Publisher: United States
Grant note: AR-55819 / NIAMS NIH HHS RR-024150 / NCRR NIH HHS HL-46493 / NHLBI NIH HHS
Language: English
Date published: 08/2009
Academic Unit: Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984047687502771

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