Skeletal muscle disuse atrophy: protection by omega-3 polyunsaturated fatty acids

Oleksandr Obrosov; Lawrence J. Coppey; Eric P. Davidson; Scott M. Ebert; Christopher M. Adams; Mark A. Yorek

doi:10.1016/j.nfs.2025.100253

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Skeletal muscle disuse atrophy: protection by omega-3 polyunsaturated fatty acids

Journal article

Open access

Peer reviewed

Skeletal muscle disuse atrophy: protection by omega-3 polyunsaturated fatty acids

Oleksandr Obrosov, Lawrence J. Coppey, Eric P. Davidson, Scott M. Ebert, Christopher M. Adams and Mark A. Yorek

NFS journal, Vol.41, 100253

12/2025

DOI: 10.1016/j.nfs.2025.100253

PMCID: PMC12747565

PMID: 41472861

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Abstract

The goal of this study was to examine benefit of omega-3 polyunsaturated fatty acids (PUFA) derived from fish oil or resolvin D1, metabolite of docosahexaenoic acid, on skeletal muscle disuse atrophy. Atrophy was induced of the left leg of C57Bl6/J male mice for 1 week.Three different treatment experimental protocols were used by feeding a diet enriched with menhaden oil or daily injections with resolvin D1 before or after immobilization.Evaluation of muscle atrophy was performed by determining the difference in weight of the tibialis anterior muscle between the immobilized (left) and mobile contralateral side (right) and by immunohistochemistry. A 2-week prevention protocol with menhaden oil enriched diet or daily injections of 2 ng/g resolvin D1 provided the greatest protection from muscle atrophy.Significant protection was also observed when dietary treatment of the mice was initiated at time of immobilization. This study demonstrated that omega-3 PUFA and metabolites provide protection toward skeletal muscle disuse atrophy.

eicosapentaenoic acid, docosahexaenoic acid

Fatty acid metabolism

Omega-3 polyunsaturated fatty acids

Resolvins

Skeletal muscle atrophy

Details

Title: Subtitle: Skeletal muscle disuse atrophy: protection by omega-3 polyunsaturated fatty acids
Creators: Oleksandr Obrosov - University of Iowa
Lawrence J. Coppey - University of Iowa
Eric P. Davidson - University of Iowa
Scott M. Ebert - Mayo Clinic
Christopher M. Adams - Mayo Clinic
Mark A. Yorek - Department of Veterans Affairs Iowa City Health Care System, Iowa City, IA 52246, United States of America
Resource Type: Journal article
Publication Details: NFS journal, Vol.41, 100253
DOI: 10.1016/j.nfs.2025.100253
PMID: 41472861
PMCID: PMC12747565
NLM abbreviation: NFS J
ISSN: 2352-3646
eISSN: 2352-3646
Publisher: Elsevier GmbH
Grant note: Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development: BX000976-11 Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development: RX000889-05, RX003826-04 National Institutes of Health: DK 126837
This material is based upon work supported by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development (BX000976-11; MAY) and Rehabilitation Research and Development (RX000889-05 and RX003826-04; MAY) and National Institutes of HealthDK 126837. The content of this manuscript is new and solely the responsibility of the authors and do not necessarily represent the official views of the granting agencies.
Language: English
Date published: 12/2025
Academic Unit: Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9985091806802771

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