Skewed X inactivation and IVF-conceived infants

Jennifer L. King; Baoli Yang; Amy E.T. Sparks; Lindsay M. Mains; Jeffrey C. Murray; Bradley J. Van Voorhis

doi:10.1016/j.rbmo.2010.01.011

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Skewed X inactivation and IVF-conceived infants

Journal article

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Peer reviewed

Skewed X inactivation and IVF-conceived infants

Jennifer L. King, Baoli Yang, Amy E.T. Sparks, Lindsay M. Mains, Jeffrey C. Murray and Bradley J. Van Voorhis

Reproductive Biomedicine Online, Vol.20(5), pp.660-663

05/01/2010

DOI: 10.1016/j.rbmo.2010.01.011

PMCID: PMC2923043

PMID: 20207584

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https://doi.org/10.1016/j.rbmo.2010.01.011View

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Abstract

The objective of this study was to investigate whether skewed X chromosome inactivation (XCI) is associated with IVF. A retrospective cohort study was performed comprising 30 female infants conceived by IVF and 44 naturally conceived control infants matched for gestational age and sex. Cord blood DNA samples were obtained and XCI patterns were analysed using a methylation-sensitive assay. Eight IVF samples and 13 control samples were excluded from the study because they were either homozygous or alleles were too similar for the assay to determine skewing. Mildly skewed XCI (80–90% inactivation of one allele) was present in two of 22 (9.1%) IVF samples and two of 31 (6.5%) control samples. Extremely skewed XCI (>90% inactivation of one allele) was found in two of 22 (9.1%) IVF samples and none of 31 control samples. Neither difference was statistically significant. However, the mean degree of skewed XCI in the IVF group was 72.0% and in the control group was 62.4% (P = 0.002). Larger studies are needed to clarify the relationship between IVF and skewed XCI.

Obstetrics and Gynecology

Details

Title: Subtitle: Skewed X inactivation and IVF-conceived infants
Creators: Jennifer L. King
Baoli Yang - University of Iowa
Amy E.T. Sparks - University of Iowa
Lindsay M. Mains
Jeffrey C. Murray
Bradley J. Van Voorhis - University of Iowa
Resource Type: Journal article
Publication Details: Reproductive Biomedicine Online, Vol.20(5), pp.660-663
DOI: 10.1016/j.rbmo.2010.01.011
PMID: 20207584
PMCID: PMC2923043
NLM abbreviation: Reprod Biomed Online
ISSN: 1472-6483
Language: English
Date published: 05/01/2010
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; BioVentures Center; Obstetrics and Gynecology; Dental Research
Record Identifier: 9983557120502771

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