Skin InteGrity in extreme preterms research NETwork (SIGNET) - improving skin care for the most immature infants

Deanne August; Sabrina de Souza; Vita Boyar; Amy Curran; Amy A Hobson; Miki Konishi; Gillion Noreiks; Kylie Pussell; Hannah Skelton; Matthew A Rysavy; Karen Walker; Marty Visscher; Pranav R Jani

doi:10.1038/s41372-025-02487-8

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Skin InteGrity in extreme preterms research NETwork (SIGNET) - improving skin care for the most immature infants

Journal article

Peer reviewed

Skin InteGrity in extreme preterms research NETwork (SIGNET) - improving skin care for the most immature infants

Deanne August, Sabrina de Souza, Vita Boyar, Amy Curran, Amy A Hobson, Miki Konishi, Gillion Noreiks, Kylie Pussell, Hannah Skelton, Matthew A Rysavy, …

Journal of perinatology

01/05/2026

DOI: 10.1038/s41372-025-02487-8

PMID: 41490935

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Abstract

Increased survival of preterm infants born <28 weeks' gestation brings new challenges for healthcare teams and families, particularly in the absence of high-quality, population-specific evidence to guide optimal skin care. Skin integrity is critical for preventing infection, reducing pain, and minimizing fluid loss. However, variations in care, delivery models, geographic settings, and clinician expertise continue to influence outcomes-impacting both immediate survival, long-term morbidity and mortality. This review outlines the key challenges associated with delivering safe and effective skin care for extremely preterm infants; identifies priority areas for research and benchmarking, and proposes a collaborative approach to address these gaps. The Skin InteGrity in extreme preterms research NETwork (SIGNET) collaborative seeks to align outcome measures, generate essential physiological data, promote knowledge exchange, and develop practical, evidence-based tools to support consistent, high-quality care for these uniquely vulnerable patients.

Details

Title: Subtitle: Skin InteGrity in extreme preterms research NETwork (SIGNET) - improving skin care for the most immature infants
Creators: Deanne August - The University of Queensland
Sabrina de Souza - The University of Queensland
Vita Boyar - Jersey Shore University Medical Center
Amy Curran - Townsville Hospital
Amy A Hobson - University of Iowa
Miki Konishi - Dokkyo Medical University
Gillion Noreiks - Royal Brisbane and Women's Hospital
Kylie Pussell - Stillbirth Foundation
Hannah Skelton - Westmead Hospital
Matthew A Rysavy - The University of Texas Health Science Center
Karen Walker - The University of Sydney
Marty Visscher - University of Cincinnati Medical Center
Pranav R Jani - Westmead Hospital
Resource Type: Journal article
Publication Details: Journal of perinatology
DOI: 10.1038/s41372-025-02487-8
PMID: 41490935
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Publisher: Springer Nature
Language: English
Electronic publication date: 01/05/2026
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9985116810102771

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