Journal article
Skin Sensitivity to Allergen Does Not Accurately Predict Airway Response to Allergen
Annals of allergy, asthma, & immunology, Vol.80(2), pp.207-211
1998
DOI: 10.1016/S1081-1206(10)62957-2
PMID: 9494456
Abstract
Allergen challenge of the asthmatic airway has become widely applied in the study of allergic asthma in humans. Skin sensitivity correlates with inhaled sensitivity in some populations. Skin test titration has been proposed as a useful tool to guide the selection of initial allergen concentration.
To determine the relationship between skin test sensitivity and inhaled reactivity to allergen.
We examined the realtionship between skin test and inhaled reactivity in 22 allergic asthmatic subjects. Methacholine bronchoprovocation was performed using a standardized tidal breathing technique. Prick skin test titrations were done using serially diluted lyophilized antigen extracts reconstituted in normal saline from 1:100,00 to 1:10. Inhaled allergen challenge was routinely performed in the morning using the same allergen employed in skin test titration.
There was no correlation between skin test threshold and the inhaled concentration required to produce a 20% fall in FEV
1 (r = 0.07;
P = .78). If subjects who manifested marked cutaneous reactivity (ie, skin reactivity at dilutions greater than 1:10,000) were excluded from analysis, there was a significant correlation between cutaneous and inhaled reactivity (r = 0.84;
P < .001).
While a correlation between skin test threshold and inhaled reactivity is present in some subjects with allergic asthma, the relationship is inconsistent.
Details
- Title: Subtitle
- Skin Sensitivity to Allergen Does Not Accurately Predict Airway Response to Allergen
- Creators
- David L Bowton - From the Department of Internal Medicine. Sections on Pulmonary, Allergy and Critical Care MedicineMary Beth Fasano - Infectious Diseases and ImmunologyDavid A Bass - From the Department of Internal Medicine. Sections on Pulmonary, Allergy and Critical Care Medicine
- Resource Type
- Journal article
- Publication Details
- Annals of allergy, asthma, & immunology, Vol.80(2), pp.207-211
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1081-1206(10)62957-2
- PMID
- 9494456
- ISSN
- 1081-1206
- eISSN
- 1534-4436
- Language
- English
- Date published
- 1998
- Academic Unit
- Stead Family Department of Pediatrics; Rheumatology, Allergy, and Immunology; Immunology; Internal Medicine
- Record Identifier
- 9984093221802771
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