Journal article
Skin and Soft Tissue Infections Due to Nontuberculous Mycobacteria
Current infectious disease reports, Vol.20(4), pp.6-17
03/19/2018
DOI: 10.1007/s11908-018-0611-3
PMID: 29556857
Abstract
This review describes recent trends in the epidemiology of nontuberculous mycobacteria (NTM), emerging pathogens, new insights into NTM pathogenesis, and advances in diagnosis and treatment.
Emerging pathogens include Mycobacterium chimaera and drug-resistant subspecies of Mycobacterium abscessus. Important virulence mechanisms of pathogenic NTM include the ability to alter the macrophage's permissiveness to intracellular bacterial growth. New diagnostic tools consist of DNA probes, gene sequencing, and matrix-assisted laser desorption ionization-time of flight. These methods allow rapid speciation of NTM species, in some cases directly from patient samples. There are few novel agents available to treat NTM, although some repurposed drugs show excellent activity. The incidence of NTM infections appears to be increasing in a number of regions around the world. Molecular methods are now the diagnostic tools of choice. Discovery of novel effective agents and/or drug combinations with greater likelihood of cure, shorter treatment duration, and fewer side effects are research priorities.
Details
- Title: Subtitle
- Skin and Soft Tissue Infections Due to Nontuberculous Mycobacteria
- Creators
- Elizabeth Ann Misch - Division of Allergy and Infectious Disease, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Medical Foundation Centennial Building, 1685 Highland Avenue, 5th floor, Madison, WI, 53705-2281, USA. eamisch@medicine.wisc.eduChristopher Saddler - Division of Allergy and Infectious Disease, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USAJames Muse Davis - Division of Infectious Disease, Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
- Resource Type
- Journal article
- Publication Details
- Current infectious disease reports, Vol.20(4), pp.6-17
- DOI
- 10.1007/s11908-018-0611-3
- PMID
- 29556857
- ISSN
- 1523-3847
- eISSN
- 1534-3146
- Language
- English
- Date published
- 03/19/2018
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093350802771
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