Journal article
Sleep Deprivation Selectively Impairs Memory Consolidation for Contextual Fear Conditioning
Learning & memory (Cold Spring Harbor, N.Y.), Vol.10(3), pp.168-176
05/2003
DOI: 10.1101/lm.48803
PMCID: PMC202307
PMID: 12773581
Abstract
Many behavioral and electrophysiological studies in animals and humans have
suggested that sleep and circadian rhythms influence memory consolidation. In
rodents, hippocampus-dependent memory may be particularly sensitive to sleep
deprivation after training, as spatial memory in the Morris water maze is
impaired by rapid eye movement sleep deprivation following training. Spatial
learning in the Morris water maze, however, requires multiple training trials
and performance, as measured by time to reach the hidden platform is
influenced by not only spatial learning but also procedural learning. To
determine if sleep is important for the consolidation of a single-trial,
hippocampus-dependent task, we sleep deprived animals for 0–5 and
5–10 h after training for contextual and cued fear conditioning. We
found that sleep deprivation from 0–5 h after training for this task
impaired memory consolidation for contextual fear conditioning whereas sleep
deprivation from 5–10 h after training had no effect. Sleep deprivation
at either time point had no effect on cued fear conditioning, a
hippocampus-independent task. Previous studies have determined that memory
consolidation for fear conditioning is impaired when protein kinase A and
protein synthesis inhibitors are administered at the same time as when sleep
deprivation is effective, suggesting that sleep deprivation may act by
modifying these molecular mechanisms of memory storage.
Details
- Title: Subtitle
- Sleep Deprivation Selectively Impairs Memory Consolidation for Contextual Fear Conditioning
- Creators
- Laurel A Graves - Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USAElizabeth A Heller - College of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USAAllan I Pack - Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USATed Abel - Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.10(3), pp.168-176
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/lm.48803
- PMID
- 12773581
- PMCID
- PMC202307
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Language
- English
- Date published
- 05/2003
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065736202771
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