Journal article
Sleep Deprivation and the Epigenome
Frontiers in neural circuits, Vol.12, pp.14-14
2018
DOI: 10.3389/fncir.2018.00014
PMCID: PMC5835037
PMID: 29535611
Abstract
Sleep deprivation disrupts the lives of millions of people every day and has a profound impact on the molecular biology of the brain. These effects begin as changes within a neuron, at the DNA and RNA level, and result in alterations in neuronal plasticity and dysregulation of many cognitive functions including learning and memory. The epigenome plays a critical role in regulating gene expression in the context of memory storage. In this review article, we begin by describing the effects of epigenetic alterations on the regulation of gene expression, focusing on the most common epigenetic mechanisms: (i) DNA methylation; (ii) histone modifications; and (iii) non-coding RNAs. We then discuss evidence suggesting that sleep loss impacts the epigenome and that these epigenetic alterations might mediate the changes in cognition seen following disruption of sleep. The link between sleep and the epigenome is only beginning to be elucidated, but clear evidence exists that epigenetic alterations occur following sleep deprivation. In the future, these changes to the epigenome could be utilized as biomarkers of sleep loss or as therapeutic targets for sleep-related disorders.
Details
- Title: Subtitle
- Sleep Deprivation and the Epigenome
- Creators
- Marie E Gaine - Department of Molecular Physiology and Biophysics, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesSnehajyoti Chatterjee - Department of Molecular Physiology and Biophysics, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesTed Abel - Department of Molecular Physiology and Biophysics, Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- Frontiers in neural circuits, Vol.12, pp.14-14
- DOI
- 10.3389/fncir.2018.00014
- PMID
- 29535611
- PMCID
- PMC5835037
- NLM abbreviation
- Front Neural Circuits
- ISSN
- 1662-5110
- eISSN
- 1662-5110
- Publisher
- Switzerland
- Grant note
- P01 AG017628 / NIA NIH HHS R01 MH099544 / NIMH NIH HHS
- Language
- English
- Date published
- 2018
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065467302771
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