Sleep Quality Is Related to Worsening Knee Pain in Those with Widespread Pain: The Multicenter Osteoarthritis Study

Zhaoli Dai; Tuhina Neogi; Carrie Brown; Michael Nevitt; Cora E Lewis; James Torner; David T Felson

doi:10.3899/jrheum.181365

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Sleep Quality Is Related to Worsening Knee Pain in Those with Widespread Pain: The Multicenter Osteoarthritis Study

Journal article

Peer reviewed

Sleep Quality Is Related to Worsening Knee Pain in Those with Widespread Pain: The Multicenter Osteoarthritis Study

Zhaoli Dai, Tuhina Neogi, Carrie Brown, Michael Nevitt, Cora E Lewis, James Torner and David T Felson

Journal of rheumatology, Vol.47(7), pp.1019-1025

07/01/2020

DOI: 10.3899/jrheum.181365

PMCID: PMC7225049

PMID: 31732550

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https://www.ncbi.nlm.nih.gov/pmc/articles/7225049View

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Abstract

We examined the association between sleep and odds of developing knee pain, and whether this relationship varied by status of widespread pain (WSP). At the 60-month visit of the Multicenter Osteoarthritis Study, sleep quality and restless sleep were each assessed by using a single item from 2 validated questionnaires. Each sleep measure was categorized into 3 levels, with poor/most restless sleep as the reference. WSP was defined as pain above and below the waist on both sides of the body and axially using a standard homunculus, based on the American College of Rheumatology criteria. Outcomes from 60-84 months included (1) knee pain worsening (KPW; defined as minimal clinically important difference in WOMAC pain), (2) prevalent, and (3) incident consistent frequent knee pain. We applied generalized estimating equations in multivariable logistic regression models. We studied 2329 participants (4658 knees; 67.9 yrs, body mass index 30.9]. We found that WSP modified the relationship between sleep quality and KPW (p = 0.002 for interaction). Among persons with WSP, OR (95% CI) for KPW was 0.53 (0.35-0.78) for those with very good sleep quality (p trend < 0.001); additionally, we found the strongest association of sleep quality in persons with > 8 painful joint sites (p trend < 0.01), but not in those with ≤ 2 painful joint sites. Similar results were observed using restless sleep, in the presence of WSP. The cross-sectional relationship between sleep and prevalence of consistent frequent knee pain was significant. Better sleep was related to less KPW with coexisting widespread pain.

KNEE OSTEOARTHRITIS PAIN

SLEEP

OSTEOARTHRITIS

WIDESPREAD PAIN

Details

Title: Subtitle: Sleep Quality Is Related to Worsening Knee Pain in Those with Widespread Pain: The Multicenter Osteoarthritis Study
Creators: Zhaoli Dai - Z. Dai, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and The University of Sydney, Faculty of Medicine and Health, School of Pharmacy; T. Neogi, MD, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; C. Brown, MS, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; M. Nevitt, PhD, Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham; J. Torner, MD, The Department of Epidemiology and the Institute for Clinical and Translational Science, The University of Iowa; D.T. Felson, MD, MPH, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and Centre for Epidemiology, University of Manchester and the NIHR Manchester BRC, Manchester University NHS Trust. zhaoli.dai-keller@sydney.edu.au
Tuhina Neogi - Z. Dai, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and The University of Sydney, Faculty of Medicine and Health, School of Pharmacy; T. Neogi, MD, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; C. Brown, MS, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; M. Nevitt, PhD, Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham; J. Torner, MD, The Department of Epidemiology and the Institute for Clinical and Translational Science, The University of Iowa; D.T. Felson, MD, MPH, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and Centre for Epidemiology, University of Manchester and the NIHR Manchester BRC, Manchester University NHS Trust
Carrie Brown - Z. Dai, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and The University of Sydney, Faculty of Medicine and Health, School of Pharmacy; T. Neogi, MD, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; C. Brown, MS, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; M. Nevitt, PhD, Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham; J. Torner, MD, The Department of Epidemiology and the Institute for Clinical and Translational Science, The University of Iowa; D.T. Felson, MD, MPH, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and Centre for Epidemiology, University of Manchester and the NIHR Manchester BRC, Manchester University NHS Trust
Michael Nevitt - Z. Dai, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and The University of Sydney, Faculty of Medicine and Health, School of Pharmacy; T. Neogi, MD, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; C. Brown, MS, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; M. Nevitt, PhD, Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham; J. Torner, MD, The Department of Epidemiology and the Institute for Clinical and Translational Science, The University of Iowa; D.T. Felson, MD, MPH, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and Centre for Epidemiology, University of Manchester and the NIHR Manchester BRC, Manchester University NHS Trust
Cora E Lewis - Z. Dai, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and The University of Sydney, Faculty of Medicine and Health, School of Pharmacy; T. Neogi, MD, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; C. Brown, MS, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; M. Nevitt, PhD, Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham; J. Torner, MD, The Department of Epidemiology and the Institute for Clinical and Translational Science, The University of Iowa; D.T. Felson, MD, MPH, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and Centre for Epidemiology, University of Manchester and the NIHR Manchester BRC, Manchester University NHS Trust
James Torner - Z. Dai, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and The University of Sydney, Faculty of Medicine and Health, School of Pharmacy; T. Neogi, MD, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; C. Brown, MS, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; M. Nevitt, PhD, Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham; J. Torner, MD, The Department of Epidemiology and the Institute for Clinical and Translational Science, The University of Iowa; D.T. Felson, MD, MPH, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and Centre for Epidemiology, University of Manchester and the NIHR Manchester BRC, Manchester University NHS Trust
David T Felson - Z. Dai, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and The University of Sydney, Faculty of Medicine and Health, School of Pharmacy; T. Neogi, MD, PhD, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; C. Brown, MS, Boston University School of Medicine, Department of Medicine, Section of Rheumatology; M. Nevitt, PhD, Epidemiology and Biostatistics, University of California, San Francisco; C.E. Lewis, MD, Department of Epidemiology, School of Public Health, University of Alabama at Birmingham; J. Torner, MD, The Department of Epidemiology and the Institute for Clinical and Translational Science, The University of Iowa; D.T. Felson, MD, MPH, Boston University School of Medicine, Department of Medicine, Section of Rheumatology, and Centre for Epidemiology, University of Manchester and the NIHR Manchester BRC, Manchester University NHS Trust
Resource Type: Journal article
Publication Details: Journal of rheumatology, Vol.47(7), pp.1019-1025
DOI: 10.3899/jrheum.181365
PMID: 31732550
PMCID: PMC7225049
NLM abbreviation: J Rheumatol
ISSN: 0315-162X
eISSN: 1499-2752
Grant note: U01 AG018947 / NIA NIH HHS U01 AG018832 / NIA NIH HHS T32 AR007598 / NIAMS NIH HHS K24 AR070892 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS R01 AR062506 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 07/01/2020
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9984214715402771

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