Journal article
Sleep and Memory: The Impact of Sleep Deprivation on Transcription, Translational Control, and Protein Synthesis in the Brain
Journal of neurochemistry, Vol.166(1), pp.24-46
07/2023
DOI: 10.1111/jnc.15787
PMCID: PMC10919414
PMID: 36802068
Abstract
In countries around the world, sleep deprivation represents a widespread problem affecting school age children, teenagers and adults. Acute sleep deprivation and more chronic sleep restriction adversely affect individual health, impairing memory and cognitive performance as well as increasing the risk and progression of numerous diseases. In mammals, the hippocampus and hippocampus-dependent memory is vulnerable to the effects of acute sleep deprivation. Sleep deprivation induces changes in molecular signaling, gene expression and may cause changes in dendritic structure in neurons. Genome wide studies have shown that acute sleep deprivation alters gene transcription, although the pool of genes affected varies between brain regions. More recently, advances in research have drawn attention to differences in gene regulation between the level of the transcriptome compared with the pool of mRNA associated with ribosomes for protein translation following sleep deprivation. Thus, in addition to transcriptional changes, sleep deprivation also affects downstream processes to alter protein translation. In this review, we focus on the multiple levels through which acute sleep deprivation impacts gene regulation, highlighting potential post-transcriptional and translational processes that may be affected by sleep deprivation. Understanding the multiple levels of gene regulation impacted by sleep deprivation is essential for future development of therapeutics that may mitigate the effects of sleep loss.
Details
- Title: Subtitle
- Sleep and Memory: The Impact of Sleep Deprivation on Transcription, Translational Control, and Protein Synthesis in the Brain
- Creators
- Lisa C Lyons - Florida State UniversityYann Vanrobaeys - University of IowaTed Abel - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neurochemistry, Vol.166(1), pp.24-46
- DOI
- 10.1111/jnc.15787
- PMID
- 36802068
- PMCID
- PMC10919414
- NLM abbreviation
- J Neurochem
- eISSN
- 1471-4159
- Grant note
- R01 AG062398 / NIA NIH HHS
- Language
- English
- Electronic publication date
- 02/18/2023
- Date published
- 07/2023
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984375355002771
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