Journal article
Sleep and memory: a molecular perspective
Trends in Neurosciences, Vol.24(4), pp.237-243
2001
DOI: 10.1016/S0166-2236(00)01744-6
PMID: 11250009
Abstract
This review synthesizes data from behavioral studies examining the role of sleep in memory storage with what is known about the molecular mechanisms of memory consolidation. There are striking similarities in the effects on memory storage of post-training pharmacological manipulations and post-training manipulations of sleep. For example, inhibition of protein synthesis is most effective if it occurs at a time post-training when rapid eye movement (REM) sleep is required for memory consolidation. The neurochemical changes that occur across sleep/wake states, especially the cholinergic changes that occur in the hippocampus during REM sleep, might provide a mechanism by which sleep modulates specific cellular signaling pathways involved in hippocampus-dependent memory storage.
Details
- Title: Subtitle
- Sleep and memory: a molecular perspective
- Creators
- Laurel Graves - Department of Biology, Neuroscience Graduate Group, University of Pennsylvania, 38th and Hamilton Walk, 319 Leidy Labs, Philadelphia, PA 19104, USAAllan Pack - Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Pennsylvania PA, USATed Abel - Department of Biology, Neuroscience Graduate Group, University of Pennsylvania, 38th and Hamilton Walk, 319 Leidy Labs, Philadelphia, PA 19104, USA
- Resource Type
- Journal article
- Publication Details
- Trends in Neurosciences, Vol.24(4), pp.237-243
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0166-2236(00)01744-6
- PMID
- 11250009
- ISSN
- 0166-2236
- eISSN
- 1878-108X
- Language
- English
- Date published
- 2001
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065834702771
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