Sleep, circadian rhythm characteristics, and melatonin levels in later life adults with and without coronary artery disease

Chooza Moon; Christopher J Benson; Alaa Albashayreh; Yelena Perkhounkova; Helen J Burgess

doi:10.5664/jcsm.10308

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Sleep, circadian rhythm characteristics, and melatonin levels in later life adults with and without coronary artery disease

Journal article

Open access

Peer reviewed

Sleep, circadian rhythm characteristics, and melatonin levels in later life adults with and without coronary artery disease

Chooza Moon, Christopher J Benson, Alaa Albashayreh, Yelena Perkhounkova and Helen J Burgess

Journal of clinical sleep medicine, Vol.19(2), pp.283-292

02/01/2023

DOI: 10.5664/jcsm.10308

PMCID: PMC9892726

PMID: 36148612

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Abstract

The purpose of this study was to conduct a comprehensive assessment of sleep and circadian rhythms in individuals with and without coronary artery disease (CAD). This was a cross-sectional study. Participants were 32 individuals, mean age = 70.9, female 46.9%, 19 with CAD, and 13 without CAD. We assessed sleep quality and 24-hour rest-activity rhythms for 14 days using wrist actigraphy and self-report measures, and circadian rhythm using dim light melatonin onset. Melatonin levels prior to habitual bedtime were significantly lower in individuals with CAD than in those without CAD (median area under the curve = 12.88 vs 26.33 pg/ml × h, = .049). The median circadian timing measured by dim light melatonin onset was the same for the 2 groups with 20:26 [hours:minutes] for individuals with CAD and 19:53 for the control group ( = .64, = .14). Compared to the control group, the CAD group had significantly lower amplitude ( = .03, =-.48), and lower overall rhythmicity (pseudo- -statistic = .004, = -.65) in their 24-hour rest-activity rhythms. This is one of the first studies to comprehensively assess both sleep and circadian rhythm in individuals with CAD. Compared to non-CAD controls, individuals with CAD had lower levels of melatonin prior to habitual bedtime and a lower 24-hour rest-activity rhythm amplitude and overall rhythmicity. Future studies using larger sample sizes should further investigate the possibility of suppressed circadian rhythmicity in individuals with CAD. Moon C, Benson CJ, Albashayreh A, Perkhounkova Y, Burgess HJ. Sleep, circadian rhythm characteristics, and melatonin levels in later life adults with and without coronary artery disease. . 2023;19(2):283-292.

Adult

Aged

Circadian Rhythm

Coronary Artery Disease

Cross-Sectional Studies

Female

Humans

Melatonin

Sleep

Details

Title: Subtitle: Sleep, circadian rhythm characteristics, and melatonin levels in later life adults with and without coronary artery disease
Creators: Chooza Moon - University of Iowa
Christopher J Benson - University of Iowa Carver College of Medicine, Department of Internal Medicine, Iowa City, Iowa
Alaa Albashayreh - University of Iowa College of Nursing, Iowa City, Iowa
Yelena Perkhounkova - University of Iowa College of Nursing, Iowa City, Iowa
Helen J Burgess - University of Michigan
Resource Type: Journal article
Publication Details: Journal of clinical sleep medicine, Vol.19(2), pp.283-292
DOI: 10.5664/jcsm.10308
PMID: 36148612
PMCID: PMC9892726
NLM abbreviation: J Clin Sleep Med
ISSN: 1550-9389
eISSN: 1550-9397
Language: English
Date published: 02/01/2023
Academic Unit: Iowa Neuroscience Institute; Cardiovascular Medicine; Nursing; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984364513602771

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