Journal article
Sleep deprivation and aging are metabolically linked across tissues
Sleep (New York, N.Y.), Vol.46(11), pp.1-12
11/08/2023
DOI: 10.1093/sleep/zsad246
PMCID: PMC11502955
PMID: 37738102
Abstract
Abstract Study objectives Insufficient sleep is a concerning hallmark of modern society because sleep deprivation (SD) is a risk factor for neurodegenerative and cardiometabolic disorders. SD imparts an aging-like effect on learning and memory, although little is known about possible common molecular underpinnings of SD and aging. Here, we examine this question by profiling metabolic features across different tissues after acute sleep deprivation in young adult and aged mice. Methods Young adult and aged mice were subjected to acute SD for five hours. Blood plasma, hippocampus and liver samples were subjected to UPLC-MS/MS based metabolic profiling. Results SD preferentially impacts peripheral plasma and liver profiles (e.g., ketone body metabolism) whereas the hippocampus is more impacted by aging. We further demonstrate that aged animals exhibit SD-like metabolic features at baseline. Hepatic alterations include parallel changes in nicotinamide metabolism between aging and SD in young animals. Overall, metabolism in young adult animals is more impacted by SD, which in turn induces aging-like features. A set of nine metabolites classifies (79% correct) based on age and sleep status across all four groups. Conclusion Our metabolic observations demonstrate striking parallels to previous observations in studies of learning and memory and define a molecular metabolic signature of sleep loss and aging.
Details
- Title: Subtitle
- Sleep deprivation and aging are metabolically linked across tissues
- Creators
- Arjun Sengupta - University of PennsylvaniaJennifer C Tudor - University of PennsylvaniaDanielle Cusmano - University of PennsylvaniaJoseph A Baur - University of PennsylvaniaTed Abel - University of PennsylvaniaAalim M Weljie - University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Sleep (New York, N.Y.), Vol.46(11), pp.1-12
- DOI
- 10.1093/sleep/zsad246
- PMID
- 37738102
- PMCID
- PMC11502955
- NLM abbreviation
- Sleep
- ISSN
- 0161-8105
- eISSN
- 1550-9109
- Grant note
- DOI: 10.13039/100006920, name: University of Pennsylvania, award: 5R21AG052905
- Language
- English
- Electronic publication date
- 09/20/2023
- Date published
- 11/08/2023
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984472533202771
Metrics
12 Record Views