Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory

Toni-Moi Prince; Mathieu Wimmer; Jennifer Choi; Robbert Havekes; Sara Aton; Ted Abel

doi:10.1016/j.nlm.2013.11.021

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Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory

Journal article

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Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory

Toni-Moi Prince, Mathieu Wimmer, Jennifer Choi, Robbert Havekes, Sara Aton and Ted Abel

Neurobiology of learning and memory, Vol.109, pp.122-130

03/2014

DOI: 10.1016/j.nlm.2013.11.021

PMCID: PMC3966473

PMID: 24380868

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Abstract

•Sleep deprivation for 3h impairs memory when onset occurs 1h after training.•Sleep deprivation for 3h impairs LTP when onset occurs 1h after training.•Sleep deprivation for 3h, beginning immediately after training, does not impair memory.•Sleep deprivation for 3h, beginning immediately after training, does not impair LTP. Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sleep deprived following training in the hippocampus-dependent object place recognition task. We found that 3h of sleep deprivation significantly impaired memory when deprivation began 1h after training. In contrast, 3h of deprivation beginning immediately post-training did not impair spatial memory. Furthermore, a 3-h sleep deprivation beginning 1h after training impaired hippocampal long-term potentiation (LTP), whereas sleep deprivation immediately after training did not affect LTP. Together, our findings define a specific 3-h critical period, extending from 1 to 4h after training, during which sleep deprivation impairs hippocampal function.

Sleep loss

Long-term potentiation

Hippocampus

Spatial memory

Details

Title: Subtitle: Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory
Creators: Toni-Moi Prince - Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA
Mathieu Wimmer - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Jennifer Choi - Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Robbert Havekes - Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Sara Aton - Department of Molecular, Cellular & Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
Ted Abel - Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Resource Type: Journal article
Publication Details: Neurobiology of learning and memory, Vol.109, pp.122-130
DOI: 10.1016/j.nlm.2013.11.021
PMID: 24380868
PMCID: PMC3966473
NLM abbreviation: Neurobiol Learn Mem
ISSN: 1074-7427
eISSN: 1095-9564
Publisher: Elsevier Inc
Language: English
Date published: 03/2014
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984065827702771

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