Journal article
Sleep deprivation impairs synaptic tagging in mouse hippocampal slices
Neurobiology of learning and memory, Vol.154, pp.136-140
10/2018
DOI: 10.1016/j.nlm.2018.03.016
PMCID: PMC6454544
PMID: 29551603
Abstract
•Synaptic tagging and capture (STC) is a form of metaplasticity.•Brief sleep deprivation (SD) in mice impairs STC at weakly stimulated synapses.•SD may affect how activity at certain synapses influences plasticity at others.
Metaplasticity refers to the ability of experience to alter synaptic plasticity, or modulate the strength of neuronal connections. Sleep deprivation has been shown to have a negative impact on synaptic plasticity, but it is unknown whether sleep deprivation also influences processes of metaplasticity. Therefore, we tested whether 5 h of total sleep deprivation (SD) in mice would impair hippocampal synaptic tagging and capture (STC), a form of heterosynaptic metaplasticity in which combining strong stimulation in one synaptic input with weak stimulation at another input allows the weak input to induce long-lasting synaptic strengthening. STC in stratum radiatum of area CA1 occurred normally in control mice, but was impaired following SD. After SD, potentiation at the weakly stimulated synapses decayed back to baseline within 2 h. Thus, sleep deprivation disrupts a prominent form of metaplasticity in which two independent inputs interact to generate long-lasting LTP.
Details
- Title: Subtitle
- Sleep deprivation impairs synaptic tagging in mouse hippocampal slices
- Creators
- Christopher G Vecsey - Neuroscience Program, Skidmore College, 815 N. Broadway, Saratoga Springs, NY 12866, United StatesTed Huang - Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, United StatesTed Abel - Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, United States
- Resource Type
- Journal article
- Publication Details
- Neurobiology of learning and memory, Vol.154, pp.136-140
- DOI
- 10.1016/j.nlm.2018.03.016
- PMID
- 29551603
- PMCID
- PMC6454544
- NLM abbreviation
- Neurobiol Learn Mem
- ISSN
- 1074-7427
- eISSN
- 1095-9564
- Publisher
- Elsevier Inc
- Grant note
- name: NIH, award: HL07953; DOI: 10.13039/100000002, name: National Institutes of Health, award: AG017628; name: SCOR, award: HL060287; name: HFSP, award: RGSP/2005
- Language
- English
- Date published
- 10/2018
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070503102771
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