Journal article
Sleep deprivation reduces the density of individual spine subtypes in a branch‐specific fashion in CA1 neurons
Journal of sleep research, Vol.31(1), pp.e13438-n/a
02/2022
DOI: 10.1111/jsr.13438
PMCID: PMC8760357
PMID: 34263991
Abstract
Summary
Sleep deprivation has a negative impact on hippocampus‐dependent memory, which is thought to depend on cellular plasticity. We previously found that 5 h of sleep deprivation robustly decreases dendritic spine density in the CA1 area of the hippocampus in adult male mice. However, recent work by others suggests that sleep deprivation increases the density of certain spine types on specific dendritic branches. Based on these recent findings and our previous work, we conducted a more in‐depth analysis of different spine types on branches 1, 2 and 5 of both apical and basal dendrites to assess whether 5 h of sleep deprivation may have previously unrecognized spine‐type and branch‐specific effects. This analysis shows no spine‐type specific changes on branch 1 and 2 of apical dendrites after sleep deprivation. In contrast, sleep deprivation decreases the number of mushroom and branched spines on branch 5. Likewise, sleep deprivation reduces thin, mushroom and filopodia spine density on branch 5 of the basal dendrites, without affecting spines on branch 1 and 2. Our findings indicate that sleep deprivation leads to local branch‐specific reduction in the density of individual spine types, and that local effects might not reflect the overall impact of sleep deprivation on CA1 structural plasticity. Moreover, our analysis underscores that focusing on a subset of dendritic branches may lead to potential misinterpretation of the overall impact of, in this case, sleep deprivation on structural plasticity.
Details
- Title: Subtitle
- Sleep deprivation reduces the density of individual spine subtypes in a branch‐specific fashion in CA1 neurons
- Creators
- Youri G. Bolsius - University of GroningenPeter Meerlo - University of GroningenMartien J. Kas - Korea Advertising SocietyTed Abel - University of IowaRobbert Havekes - University of Groningen
- Resource Type
- Journal article
- Publication Details
- Journal of sleep research, Vol.31(1), pp.e13438-n/a
- DOI
- 10.1111/jsr.13438
- PMID
- 34263991
- PMCID
- PMC8760357
- NLM abbreviation
- J Sleep Res
- ISSN
- 0962-1105
- eISSN
- 1365-2869
- Number of pages
- 6
- Grant note
- National Institute of Mental Health (R01 MH117964)
- Language
- English
- Date published
- 02/2022
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984293415302771
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