Sleep-disordered breathing, brain volume, and cognition in older individuals with heart failure

Chooza Moon; Kelsey E Melah; Sterling C Johnson; Lisa C Bratzke

doi:10.1002/brb3.1029

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Sleep-disordered breathing, brain volume, and cognition in older individuals with heart failure

Journal article

Open access

Peer reviewed

Sleep-disordered breathing, brain volume, and cognition in older individuals with heart failure

Chooza Moon, Kelsey E Melah, Sterling C Johnson and Lisa C Bratzke

Brain and Behavior, Vol.8(7), e01029

06/19/2018

DOI: 10.1002/brb3.1029

PMCID: PMC6043704

PMID: 29920994

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Published (Version of record)Brain and Behavior. 2018;8: e01029.

Abstract

Background Sleep-disordered breathing is common in individuals with heart failure and may contribute to changes in the brain and decreased cognition. However, limited research has explored how the apnea-hypopnea index contributes to brain structure and cognition in this population. The aims of this study were to explore how the apnea-hypopnea index is associated with brain volume and cognition in heart failure patients. Methods Data of 28 heart failure patients (mean age = 67.93; SD = 5.78) were analyzed for this cross-sectional observational study. We evaluated the apnea-hypopnea index using a portable multichannel sleep-monitoring device. All participants were scanned using 3.0 Tesla magnetic resonance imaging and neuropsychological tests. Brain volume was evaluated using a voxel-based morphometry method with T1-weighted images. We used multiple regressions to analyze how the apnea-hypopnea index is associated with brain volume and cognition. Results We found an inverse association between apnea-hypopnea index scores and white matter volume ([beta] = -0.002, p = 0.026), but not in gray matter volume ([beta] = -0.001, p = 0.237). Higher apnea-hypopnea index was associated with reduced regional gray and white matter volume (p 0.001, uncorrected). Cognitive scores were not associated with the apnea-hypopnea index (p-values were >0.05). Conclusion Findings from this study provide exploratory evidence that higher apnea‐hypopnea index may be associated with greater brain volume reduction in heart failure patients. Future studies are needed to establish the relationship between sleep‐disordered breathing, brain volume, and cognition in heart failure samples.

Sleep Apnea

Heart Failure

Medicine, Experimental

Medical research

Sleep apnea syndromes

Cognition

Cardiac patients

OAfund

Details

Title: Subtitle: Sleep-disordered breathing, brain volume, and cognition in older individuals with heart failure
Creators: Chooza Moon - University of Iowa, Nursing
Kelsey E Melah
Sterling C Johnson
Lisa C Bratzke
Resource Type: Journal article
Publication Details: Brain and Behavior, Vol.8(7), e01029
DOI: 10.1002/brb3.1029
PMID: 29920994
PMCID: PMC6043704
NLM abbreviation: Brain Behav
ISSN: 2162-3279
eISSN: 2162-3279
Publisher: Wiley Subscription Services, Inc
Grant note: DISCLOSURE STATEMENT: The project described in this study was supported by the Sigma Theta Tau Beta-Eta at Large chapter and the National Institute of Nursing Research, award Number R00NR012773 (Brain Alterations and Cognitive Impairment in Older Adults with Heart Failure). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Nursing Research or the National Institutes of Health. The authors have indicated no financial conflict of interest.
Language: English
Date published: 06/19/2018
Description audience: Academic
Academic Unit: Iowa Neuroscience Institute; Nursing
Record Identifier: 9983763491902771

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