Journal article
Sleep disturbance, distress, and quality of life in ovarian cancer patients during the first year after diagnosis
Cancer, Vol.119(17), pp.3234-3241
09/01/2013
DOI: 10.1002/cncr.28188
PMCID: PMC3775963
PMID: 23797955
Abstract
Sleep disturbance is a common clinical complaint of oncology patients and contributes to substantial morbidity. However, because most sleep studies have been cross-sectional, associations between sleep quality and distress in patients with ovarian cancer over time remain unclear. This prospective longitudinal study examined rates of sleep disturbance; contributions of depression, anxiety, and medication use in sleep disturbance; and associations between sleep quality and quality of life (QOL) during the first year after diagnosis among women with ovarian cancer. Women with a pelvic mass completed measures of sleep quality, depression, anxiety, and QOL before surgery. Those diagnosed with primary epithelial ovarian, fallopian tube, or peritoneal cancer repeated surveys at 6 months and 1 year after diagnosis. Mixed modeling was used to examine trajectories of psychosocial measures over time, as well as associations between changes in distress and sleep quality. Relationships between changes in sleep and QOL were also examined. The majority of patients reported disturbed global sleep (Pittsburgh Sleep Quality Index > 5) at all 3 time points. Medications for sleep and pain were associated with worse sleep at all time points. Greater increases in depression were associated with increased disturbances in sleep quality over time (P < .04). Worsening sleep was also associated with declines in QOL over time (P < .001). Sleep disturbance is common and persistent in women with ovarian cancer, and is linked to depressive symptoms and QOL. Pharmacologic treatment does not appear to adequately address this problem. Results highlight the need for ongoing screening and intervention for sleep disturbance in this population.
Details
- Title: Subtitle
- Sleep disturbance, distress, and quality of life in ovarian cancer patients during the first year after diagnosis
- Creators
- Lauren Clevenger - Department of Psychology, University of Iowa, Iowa City, IowaAndrew SchrepfKoenraad DegeestDavid BenderMichael GoodheartAmina AhmedLaila DahmoushFrank PenedoJoseph A Lucci IIIPremal H ThakerLuis MendezAnil K SoodGeorge M SlavichSusan K Lutgendorf
- Resource Type
- Journal article
- Publication Details
- Cancer, Vol.119(17), pp.3234-3241
- DOI
- 10.1002/cncr.28188
- PMID
- 23797955
- PMCID
- PMC3775963
- NLM abbreviation
- Cancer
- ISSN
- 0008-543X
- eISSN
- 1097-0142
- Publisher
- United States
- Grant note
- R01 CA140933 / NCI NIH HHS CA140933 / NCI NIH HHS R21 CA088293 / NCI NIH HHS CA104825 / NCI NIH HHS R01 CA104825 / NCI NIH HHS
- Language
- English
- Date published
- 09/01/2013
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Pathology; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9983931825702771
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