Journal article
Sleep duration associated with altered oral microbiome diversity and composition in the NIH AARP cohort
Sleep advances, Vol.6(2), zpaf023
04/10/2025
DOI: 10.1093/sleepadvances/zpaf023
PMCID: PMC12120444
PMID: 40444264
Abstract
STUDY OBJECTIVES
The microbiome is proposed as a contributor to the adverse health impacts from altered sleep. The oral microbiome is a multifaceted microbial community that influences many health functions. However, data on the relationship between sleep and the oral microbiome are limited, and no studies have incorporated lifestyle and environmental exposures.
METHODS
Within a subset (N=1,139) of the NIH-AARP cohort, we examined the association between self-reported sleep duration and the oral microbiome via 16S rRNA gene amplicon sequencing. Statistical models were adjusted for demographic characteristics. Additional models examined the role of various lifestyle and neighborhood exposures on the sleep-oral microbiome association.
RESULTS
Compared to participants reporting the recommended 7-8 hours average sleep duration (n=702), those reporting short sleep (6 or fewer hours, n=284) had consistently decreased within-sample oral microbial diversity [e.g. number of observed taxa difference -8.681, p-value=0.009]. Several bacterial taxa were more likely to be absent in the short sleep group. We found a higher relative abundance of Streptococcus and Rothia, and lower abundance of Fusobacterium, Atopobium, and Campylobacter in the short compared to the recommended sleep duration group. Results were consistent when controlling for lifestyle and neighborhood factors.
CONCLUSIONS
Our findings provide evidence for an association of short sleep duration with oral microbial diversity and composition. This suggests that oral microbes may play a possible mechanistic role related to sleep health. Improved understanding of physiological pathways can aid in the design of interventions that may beneficially improve overall sleep health.
Details
- Title: Subtitle
- Sleep duration associated with altered oral microbiome diversity and composition in the NIH AARP cohort
- Creators
- Kathryn R DaltonVicky C ChangMikyeong LeeKatherine MakiPedro Saint-MauriceVaishnavi PurandareXing HuaYunhu WanCasey L DagnallKristine JonesBelynda D HicksAmy HutchinsonLinda M LiaoMitchell H GailJianxin ShiRashmi SinhaChristian C AbnetStephanie J LondonEmily Vogtmann
- Resource Type
- Journal article
- Publication Details
- Sleep advances, Vol.6(2), zpaf023
- DOI
- 10.1093/sleepadvances/zpaf023
- PMID
- 40444264
- PMCID
- PMC12120444
- NLM abbreviation
- Sleep Adv
- ISSN
- 2632-5012
- eISSN
- 2632-5012
- Publisher
- Oxford Academic; OXFORD
- Language
- English
- Electronic publication date
- 04/17/2025
- Date published
- 04/10/2025
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984813150902771
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