Journal article
Sleep duration, cognitive decline, and dementia risk in older women
Alzheimer's & dementia, Vol.12(1), pp.21-33
01/2016
DOI: 10.1016/j.jalz.2015.03.004
PMCID: PMC4679723
PMID: 26086180
Abstract
Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking.
We conducted a prospective study on 7444 community-dwelling women (aged 65–80 y) with self-reported sleep duration, within the Women's Health Initiative Memory Study in 1995–2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics.
We found a statistically significant (P = .03) V-shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate-adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V-shaped association was found with cognitive decline.
In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors.
Details
- Title: Subtitle
- Sleep duration, cognitive decline, and dementia risk in older women
- Creators
- Jiu-Chiuan Chen - Department of Preventive Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USAMark A Espeland - Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USARobert L Brunner - Department of Family and Community Medicine, University of Nevada School of Medicine, Reno, NV, USALaura C Lovato - Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USARobert B Wallace - Departments of Epidemiology & Medicine, University of Iowa, Iowa City, IA, USAXiaoyan Leng - Division of Public Health Sciences, Department of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USALawrence S Phillips - Atlanta VA Medical Center and Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USAJennifer G Robinson - Departments of Epidemiology & Medicine, University of Iowa, Iowa City, IA, USAJane M Kotchen - Department of Population Health, Medical College of Wisconsin, Milwaukee, WI, USAKaren C Johnson - Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USAJoAnn E Manson - Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USAMarcia L Stefanick - Department of Medicine, Stanford University, Stanford, CA, USAGloria E Sarto - University of Wisconsin Center for Women's Health Research, Madison, WI, USAW. Jerry Mysiw - Department of Physical Medicine and Rehabilitation, Ohio State University, Columbus, OH, USA
- Resource Type
- Journal article
- Publication Details
- Alzheimer's & dementia, Vol.12(1), pp.21-33
- DOI
- 10.1016/j.jalz.2015.03.004
- PMID
- 26086180
- PMCID
- PMC4679723
- NLM abbreviation
- Alzheimers Dement
- ISSN
- 1552-5260
- eISSN
- 1552-5279
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100005266, name: Women's Health Initiative; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100007154, name: Wake Forest University; DOI: 10.13039/100009333, name: Society for the History of Psychology, award: 08‐144
- Language
- English
- Date published
- 01/2016
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983995033502771
Metrics
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