Sleep homeostasis in infant rats

Mark S Blumberg; Jessica E Middlemis-Brown; Eric D Johnson

doi:10.1037/0735-7044.118.6.1253

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Journal article

Peer reviewed

Sleep homeostasis in infant rats

Mark S Blumberg, Jessica E Middlemis-Brown and Eric D Johnson

Behavioral neuroscience, Vol.118(6), pp.1253-1261

12/2004

DOI: 10.1037/0735-7044.118.6.1253

PMCID: PMC2394862

PMID: 15598134

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Abstract

Homeostatic regulation is a defining characteristic of sleep but has rarely been examined in infants. This study presents an automated method of sleep deprivation in which 5-day-old rats were shocked whenever the nuchal muscle became atonic. The intensity of shock was always set at the minimal level required to maintain arousal. Deprived pups exhibited rapid increases in sleep pressure, as evidenced by increased attempts to enter sleep and subsequent increases in sensory threshold; this increased sensory threshold was not due to sensory adaptation of peripheral receptors. In addition, myoclonic twitching was suppressed during the 30-min deprivation period, leading to rebound twitching during recovery sleep. These results provide the earliest demonstration of the homeostatic regulation of sleep in an altricial mammal.

Animals, Newborn

Electroshock - adverse effects

Sensory Thresholds

Rats

Male

Nucleus Accumbens - radiation effects

Nucleus Accumbens - physiology

Rats, Sprague-Dawley

Myoclonus - physiopathology

Behavior, Animal

Sleep Deprivation - physiopathology

Animals

Analysis of Variance

Time Factors

Homeostasis - physiology

Myoclonus - etiology

Female

Sleep - physiology

Electromyography - methods

Dose-Response Relationship, Radiation

Details

Title: Subtitle: Sleep homeostasis in infant rats
Creators: Mark S Blumberg - Program in Behavioral and Cognitive Neuroscience, Department of Psychology, University of Iowa, Iowa City, IA 52242, USA. mark-blumberg@uiowa.edu
Jessica E Middlemis-Brown
Eric D Johnson
Resource Type: Journal article
Publication Details: Behavioral neuroscience, Vol.118(6), pp.1253-1261
DOI: 10.1037/0735-7044.118.6.1253
PMID: 15598134
PMCID: PMC2394862
NLM abbreviation: Behav Neurosci
ISSN: 0735-7044
eISSN: 1939-0084
Publisher: United States
Grant note: MH50701 / NIMH NIH HHS MH66424 / NIMH NIH HHS K02 MH066424-06 / NIMH NIH HHS R29 MH050701 / NIMH NIH HHS R01 MH050701-13 / NIMH NIH HHS R01 MH050701 / NIMH NIH HHS K02 MH066424 / NIMH NIH HHS HD38708 / NICHD NIH HHS
Language: English
Date published: 12/2004
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology
Record Identifier: 9984002335702771

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