Journal article
Sleep is enhanced in aged male mice that overexpress calcium/calmodulin-dependent protein kinase IV
Frontiers in neuroscience, Vol.19, 1596602
06/01/2025
DOI: 10.3389/fnins.2025.1596602
PMCID: PMC12170523
PMID: 40529249
Abstract
The dysregulation of sleep–wake patterns that occurs during aging is well documented and coincides with changes in intracellular signaling pathways that regulate sleep, such as the calcium/calmodulin-dependent protein kinase (CaMKII)/cyclic-AMP response element-binding protein (CREB) pathway. However, much less is known about the relationship between other CREB-activating members of the CaMK family, such as calcium/calmodulin-dependent protein kinase IV (CaMKIV), and the regulation of sleep. Using 2- to 4-month-old (young adult) and 22- to 24-month-old (aged) male and female CaMKIV-overexpressing (CaMKIV-OE) mice, we observed that overexpression of CaMKIV in the forebrain decreased wakefulness and increased the amount of non-rapid eye movement (NREM) and rapid eye movement (REM) sleep in aged male mice, but not young adult male mice, in comparison to age- and sex-matched controls. Conversely, female mice overexpressing CaMKIV displayed no significant differences in the percentage of time spent in each vigilance state compared to their wild-type counterparts, regardless of age. While CaMKIV overexpression also led to more sleep–wake fragmentation in young adult and aged male mice, aged female mice displayed more consolidated NREM sleep. Overall, our results suggest that CaMKIV overexpression enhances sleep in aged male mice, and differentially affects sleep–wake architecture based on sex and age, providing insights into the potential mechanism by which CaMKIV overexpression enhances memory.
Details
- Title: Subtitle
- Sleep is enhanced in aged male mice that overexpress calcium/calmodulin-dependent protein kinase IV
- Creators
- Sierra P. Feeney - Saint Joseph's UniversityErin Threlfall - Saint Joseph's UniversityJames M. Bilboa - Saint Joseph's UniversityChristopher C. Angelakos - University of PennsylvaniaMathieu E. Wimmer - Temple UniversitySatoshi Kida - The University of TokyoTed Abel - University of Iowa, Iowa Neuroscience InstituteJennifer C. Tudor - Saint Joseph's University
- Resource Type
- Journal article
- Publication Details
- Frontiers in neuroscience, Vol.19, 1596602
- DOI
- 10.3389/fnins.2025.1596602
- PMID
- 40529249
- PMCID
- PMC12170523
- NLM abbreviation
- Front Neurosci
- ISSN
- 1662-453X
- eISSN
- 1662-453X
- Publisher
- Frontiers Media S.A; LAUSANNE
- Grant note
- NIH: P50AG017628, R01AG062398 Roy J. Carver Chair in NeuroscienceDirk Warren '50 Sesquicentennial Faculty Chair of STEM disciplines
The author(s) declare that financial support was received for the research and/or publication of this article. This study was supported by the NIH P50AG017628 (PI: Allan Pack) and R01AG062398 (contact PI: TA, co-I JT), the Roy J. Carver Chair in Neuroscience (TA), and the Dirk Warren '50 Sesquicentennial Faculty Chair of STEM disciplines (JT).
- Language
- English
- Date published
- 06/01/2025
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984829026302771
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