Journal article
Sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives
Schizophrenia research, Vol.274, pp.473-485
12/2024
DOI: 10.1016/j.schres.2024.10.026
Abstract
Sleep spindles mediate sleep-dependent memory consolidation, particularly when coupled to neocortical slow oscillations (SOs). Schizophrenia is characterized by a deficit in sleep spindles that correlates with reduced overnight memory consolidation. Here, we examined sleep spindle activity, SO-spindle coupling, and both motor procedural and verbal declarative memory consolidation in early course, minimally medicated psychosis patients and non-psychotic first-degree relatives. Using a four-night experimental procedure, we observed significant deficits in spindle density and amplitude in patients relative to controls that were driven by individuals with schizophrenia. Schizophrenia patients also showed reduced sleep-dependent consolidation of motor procedural memory, which correlated with lower spindle density. Contrary to expectations, there were no group differences in the consolidation of declarative memory on a word pairs task. Nor did the relatives of patients differ in spindle activity or memory consolidation compared with controls, however increased consistency in the timing of SO-spindle coupling were seen in both patients and relatives. Our results extend prior work by demonstrating correlated deficits in sleep spindles and sleep-dependent motor procedural memory consolidation in early course, minimally medicated patients with schizophrenia, but not in first-degree relatives. This is consistent with other work in suggesting that impaired sleep-dependent memory consolidation has some specificity for schizophrenia and is a core feature rather than reflecting the effects of medication or chronicity.
Details
- Title: Subtitle
- Sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives
- Creators
- Dan Denis - University of YorkBengi Baran - University of IowaDimitrios Mylonas - Harvard Medical SchoolCourtney Spitzer - Beth Israel Deaconess Medical CenterNicolas Raymond - Beth Israel Deaconess Medical CenterChristine Talbot - Massachusetts General HospitalErin Kohnke - Massachusetts General HospitalOlivia Larson - Massachusetts General HospitalRobert Stickgold - Harvard Medical SchoolMatcheri Keshavan - Harvard Medical SchoolDara S. Manoach - Harvard Medical School
- Resource Type
- Journal article
- Publication Details
- Schizophrenia research, Vol.274, pp.473-485
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.schres.2024.10.026
- ISSN
- 0920-9964
- eISSN
- 1573-2509
- Grant note
- National Institutes of Health: R01MH107579-04, K01MH114012, 1UL1TR002541-01
This work was supported by National Institutes of Health R01MH107579-04, awarded to MK, DSM, and RS; K01MH114012, awarded to BB; and 1UL1TR002541-01 awarded to the MGH Clinical Research Center. The authors declare no competing financial interests or potential conflicts of interest.
- Language
- English
- Date published
- 12/2024
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984745355302771
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