Journal article
Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
Frontiers in oncology, Vol.9, pp.611-611
07/09/2019
DOI: 10.3389/fonc.2019.00611
PMCID: PMC6629774
PMID: 31338332
Abstract
The Sleeping Beauty (SB) transposon insertional mutagenesis system offers a streamlined approach to identify genetic drivers of cancer. With a relatively random insertion profile, SB is uniquely positioned for conducting unbiased forward genetic screens. Indeed, SB mouse models of cancer have revealed insights into the genetics of tumorigenesis. In this review, we highlight experiments that have exploited the SB system to interrogate the genetics of cancer in distinct biological contexts. We also propose experimental designs that could further our understanding of the relationship between tumor microenvironment and tumor progression.
Details
- Title: Subtitle
- Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics
- Creators
- Amy Guimaraes-Young - Roy J. and Lucille A. Carver College of MedicineCharlotte R. Feddersen - Roy J. and Lucille A. Carver College of MedicineAdam J. Dupuy - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Frontiers in oncology, Vol.9, pp.611-611
- DOI
- 10.3389/fonc.2019.00611
- PMID
- 31338332
- PMCID
- PMC6629774
- NLM abbreviation
- Front Oncol
- ISSN
- 2234-943X
- eISSN
- 2234-943X
- Publisher
- Frontiers Media S.A
- Language
- English
- Date published
- 07/09/2019
- Academic Unit
- Anatomy and Cell Biology; Pathology
- Record Identifier
- 9984284346702771
Metrics
12 Record Views