Journal article
Small Colonies, Bigger Problems? New Evidence That Staphylococcus aureus Small Colony Variants Can Worsen Lung Inflammation in Cystic Fibrosis Rats
Infection and immunity, Vol.90(11), pp.e0041322-e0041322
11/17/2022
DOI: 10.1128/iai.00413-22
PMCID: PMC9670989
PMID: 36286497
Abstract
Staphylococcus aureus is the most prevalent cystic fibrosis (CF) pathogen. During chronic airway infections, S. aureus adaptation to antibiotics includes evolving small colony variants (SCVs). Observational studies correlate SCVs with deteriorating lung function in CF, but it is unclear whether SCVs cause disease progression or if they are markers of intensified treatment. G. E. Bollar, J. D. Keith, A. M. Oden, M. R. Kiedrowski, and S. E. Birket (Infect Immun 90:e00237-22, 2022, https://doi.org/10.1128/iai.00237-22) provide intriguing new experimental evidence that an SCV elicits greater inflammation than its normal colony progenitor strain in CF rats.
Details
- Title: Subtitle
- Small Colonies, Bigger Problems? New Evidence That Staphylococcus aureus Small Colony Variants Can Worsen Lung Inflammation in Cystic Fibrosis Rats
- Creators
- Anthony J. Fischer - Univ Iowa, Div Pediat Pulmonol, Stead Family Dept Pediat, Carver Coll Med, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.90(11), pp.e0041322-e0041322
- Publisher
- Amer Soc Microbiology
- DOI
- 10.1128/iai.00413-22
- PMID
- 36286497
- PMCID
- PMC9670989
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Number of pages
- 4
- Language
- English
- Date published
- 11/17/2022
- Academic Unit
- Pulmonary Medicine; Stead Family Department of Pediatrics
- Record Identifier
- 9984354151102771
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