Journal article
Small Split Pediatric Kidneys to Expand the Donor Pool: An Analysis of Scientific Registry of Transplant Recipients (SRTR) Data
Transplantation, Vol.103(12), pp.2549-2557
12/01/2019
DOI: 10.1097/TP.0000000000002706
PMID: 30893290
Abstract
Background. Increased use of pediatric deceased donor kidneys could enlarge the deceased donor kidney pool. Kidney transplant outcomes from small pediatric donors were compared with those from ideal kidney (IK) and expanded criteria kidney (ECK) donors to understand the optimal use of pediatric donor kidneys. Methods. Kaplan-Meier analyses compared long-term patient and death-censored graft survival of en bloc kidney (EBK) and split kidney (SpK) transplants from small pediatric donors (aged <= 8 y and weight <30 kg) with those from IK and ECK. Posttransplant serum creatinine) was compared among these cohorts. Deceased donor kidney disposition was determined from small pediatric donors with >= 1 organ transplanted. Results. Patient and death-censored graft survival were similar among recipients of IK, EBK, and SpK transplants, and were superior to those of recipients of ECK. EBK and SpK transplants from donors 5-30 kg had first-year graft loss similar to ECK. Long-term graft survival and serum creatinine with kidneys from SpK donors >10 kg were better than that with ECK donors. About 3901 transplants were performed from 3660 pediatric donors (53% yield). Conclusions. Pediatric kidneys can augment the kidney donor pool and should not be considered ECK. If 90% of kidneys from donors (aged <= 8 y and weight <30 kg) with >= 1 organ transplanted been used (as SpK when >10 kg) an additional 159 kidney transplants per year could have been performed. Expanding the use of pediatric kidneys should be further explored by the transplant community.
Details
- Title: Subtitle
- Small Split Pediatric Kidneys to Expand the Donor Pool: An Analysis of Scientific Registry of Transplant Recipients (SRTR) Data
- Creators
- Manish Suneja - Roy J. and Lucille A. Carver College of MedicineSarat Kuppachi - University of IowaDaniel Katz - Roy J. and Lucille A. Carver College of MedicineLawrence Hunsicker - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.103(12), pp.2549-2557
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/TP.0000000000002706
- PMID
- 30893290
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Number of pages
- 9
- Language
- English
- Date published
- 12/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Surgery; Nephrology; Internal Medicine
- Record Identifier
- 9984322797602771
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