Small tissue chips with big opportunities for space medicine

Xuan Mu; Weishen He; Victoria Abril  Manjarrez Rivera; Raul Armando Duran De Alba; Dava J Newman; Yu Shrike Zhang

doi:10.1016/j.lssr.2022.09.002

Back

Small tissue chips with big opportunities for space medicine

Journal article

Open access

Peer reviewed

Small tissue chips with big opportunities for space medicine

Xuan Mu, Weishen He, Victoria Abril Manjarrez Rivera, Raul Armando Duran De Alba, Dava J Newman and Yu Shrike Zhang

Life Sciences in Space Research, Vol.35, pp.150-157

11/03/2022

DOI: 10.1016/j.lssr.2022.09.002

Files and links (1)

url

https://doi.org/10.1016/j.lssr.2022.09.002View

Published (Version of record) Open Access

Abstract

The spaceflight environment, including microgravity and radiation, may have considerable effects on the health and performance of astronauts, especially for long-duration and Martian missions. Conventional on-ground and in-space experimental approaches have been employed to investigate the comprehensive biological effects of the spaceflight environment. As a class of recently emerging bioengineered in vitro models, tissue chips are characterized by a small footprint, potential automation, and the recapitulation of tissue-level physiology, thus promising to help provide molecular and cellular insights into space medicine. Here, we briefly review the technical advantages of tissue chips and discuss specific on-chip physiological recapitulations. Several tissue chips have been launched into space, and more are poised to come through multi-agency collaborations, implying an increasingly important role of tissue chips in space medicine.

Microfluidics

Spaceflight

Microgravity

Radiation

Drug development

Details

Title: Subtitle: Small tissue chips with big opportunities for space medicine
Creators: Xuan Mu - University of Iowa, Roy J. Carver Department of Biomedical Engineering
Weishen He (Author) - Harvard University
Victoria Abril Manjarrez Rivera (Author) - Harvard University
Raul Armando Duran De Alba (Author) - Harvard University
Dava J Newman (Author) - Massachusetts Institute of Technology
Yu Shrike Zhang - Brigham and Women's Hospital
Resource Type: Journal article
Publication Details: Life Sciences in Space Research, Vol.35, pp.150-157
DOI: 10.1016/j.lssr.2022.09.002
ISSN: 2214-5532
eISSN: 2214-5524
Publisher: Elsevier
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: R00CA201603, R21EB025270, UG3TR003274; DOI: 10.13039/100008552, name: Brigham Research Institute
Language: English
Electronic publication date: 09/08/2022
Date published: 11/03/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984304556302771

Metrics

75 Record Views

22 Times Cited - Web of Science

See more details