Journal article
Small volume biopsy diagnostic yield at initial diagnosis versus recurrence/transformation of follicular lymphoma: A retrospective Cyto-Heme Interinstitutional Collaborative study
Cancer cytopathology, Vol.131(5), pp.279-288
05/2023
DOI: 10.1002/cncy.22676
PMCID: PMC10557381
PMID: 36573933
Abstract
BackgroundFew studies have evaluated diagnostic yield of small volume biopsies (SVB) for the diagnosis and management of follicular lymphoma (FL). MethodsThe authors performed a multi-institutional retrospective analysis of SVBs including fine-needle aspiration (FNA) and needle core biopsy (NCB) for initial FL diagnosis and suspected recurrence or transformation of FL. A total of 676 workups beginning with SVB were assessed for the mean number of biopsies per workup, the proportion of workups requiring multiple biopsies, and the proportion with a complete diagnosis including grade, on initial biopsy. ResultsCompared to workups performed for question transformation/recurrence, those done for initial FL diagnosis were significantly more likely to require multiple biopsies (p < .01), had a higher mean number of biopsies per workup (1.7 vs. 1.1, absolute standardized difference = 1.1), and a lower complete diagnosis rate at initial biopsy (39% vs. 56%). At initial FL diagnosis, NCB +/- FNA was associated with fewer biopsies per workup compared to FNA +/- CB (1.2 vs. 1.9), fewer workups requiring multiple biopsies (23% vs. 83%), and a higher complete diagnosis rate (71% vs. 18%). In contrast, during assessment for transformation/recurrence, NCB and FNA showed a similar mean number of biopsies per workup (1.2 vs. 1.2) and few workups required multiple biopsies (6% vs. 19%). ConclusionsSVB at initial FL diagnosis often required additional biopsies to establish a complete diagnosis. In contrast, when assessing for transformed/recurrent FL, additional biopsies were generally not obtained regardless of SVB type, suggesting that in these clinical settings SVB may be sufficient for clinical decision-making.
Details
- Title: Subtitle
- Small volume biopsy diagnostic yield at initial diagnosis versus recurrence/transformation of follicular lymphoma: A retrospective Cyto-Heme Interinstitutional Collaborative study
- Creators
- Megan J Fitzpatrick - Massachusetts General HospitalVandana Sundaram - Stanford UniversityAmy Ly - Massachusetts General HospitalJeremy S. Abramson - Massachusetts General HospitalRonald Balassanian - University of California, San FranciscoMatthew C. Cheung - Sunnybrook Health Science CentreStephen L. Cook - San Francisco VA Medical CenterLorenzo Falchi - Memorial Sloan Kettering Cancer CenterAnnabel K Frank - University of California, San FranciscoSrishti Gupta - University of Virginia Medical CenterRobert P Hasserjian - Massachusetts General HospitalOscar Lin - Memorial Sloan Kettering Cancer CenterSteven R. Long - University of California, San FranciscoJoshua R. Menke - Stanford UniversityEric Mou - University of IowaDaniel R. Reed - Atrium Health Wake Forest BaptistRoberto Ruiz-Cordero - University of California, San FranciscoAshley K Volaric - University of Virginia Medical CenterLinlin Wang - University of California, San FranciscoKwun Wah Wen - University of California, San FranciscoYi Xie - University of California, San FranciscoSara L Zadeh - University of Virginia Medical CenterDita Gratzinger - Stanford University
- Resource Type
- Journal article
- Publication Details
- Cancer cytopathology, Vol.131(5), pp.279-288
- DOI
- 10.1002/cncy.22676
- PMID
- 36573933
- PMCID
- PMC10557381
- NLM abbreviation
- Cancer Cytopathol
- ISSN
- 1934-662X
- eISSN
- 1934-6638
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- P30CA008748 / Memorial Sloan Kettering Cancer Center
- Language
- English
- Electronic publication date
- 12/27/2022
- Date published
- 05/2023
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359848202771
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