Journal article
Small‐Molecule Compounds Exhibiting Target‐Mediated Drug Disposition (TMDD): A Minireview
Journal of clinical pharmacology, Vol.57(2), pp.137-150
02/2017
DOI: 10.1002/jcph.804
PMID: 27489162
Abstract
Nonlinearities are commonplace in pharmacokinetics, and 1 special source is the saturable binding of the drug to a high‐affinity, low‐capacity target, a phenomenon known as target‐mediated drug disposition (TMDD). Compared with large‐molecule compounds undergoing TMDD, which has been well recognized due to its high prevalence, TMDD in small‐molecule compounds is more counterintuitive and has not been well appreciated. With more and more potent small‐molecule drugs acting on highly specific targets being developed as well as increasingly sensitive analytical techniques becoming available, many small‐molecule compounds have recently been reported to have nonlinear pharmacokinetics imparted by TMDD. To expand our current knowledge of TMDD in small‐molecule compounds and increase the awareness of this clinically important phenomenon, this minireview provides an overview of the small‐molecule compounds that demonstrate nonlinear pharmacokinetics imparted by TMDD. The present review also summarizes the general features of TMDD in small‐molecule compounds and highlights the differences between TMDD in small‐molecule compounds and large‐molecule compounds.
Details
- Title: Subtitle
- Small‐Molecule Compounds Exhibiting Target‐Mediated Drug Disposition (TMDD): A Minireview
- Creators
- Guohua An - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of clinical pharmacology, Vol.57(2), pp.137-150
- DOI
- 10.1002/jcph.804
- PMID
- 27489162
- ISSN
- 0091-2700
- eISSN
- 1552-4604
- Number of pages
- 14
- Language
- English
- Date published
- 02/2017
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065312302771
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