Smaller hippocampal volume in current but not in past depression in comparison to healthy controls: Minor evidence from an older adults sample

Ismaïl Bensassi; Jorge Lopez-Castroman; Jerome J Maller; Chantal Meslin; Marilyn Wyart; Karen Ritchie; Philippe Courtet; Sylvaine Artero; Raffaella Calati

doi:10.1016/j.jpsychires.2018.04.008

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Smaller hippocampal volume in current but not in past depression in comparison to healthy controls: Minor evidence from an older adults sample

Journal article

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Smaller hippocampal volume in current but not in past depression in comparison to healthy controls: Minor evidence from an older adults sample

Ismaïl Bensassi, Jorge Lopez-Castroman, Jerome J Maller, Chantal Meslin, Marilyn Wyart, Karen Ritchie, Philippe Courtet, Sylvaine Artero and Raffaella Calati

Journal of psychiatric research, Vol.102, pp.159-167

07/2018

DOI: 10.1016/j.jpsychires.2018.04.008

PMID: 29665490

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http://hdl.handle.net/1885/143601View

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Abstract

Structural neuroimaging studies revealed a consistent pattern of volumetric reductions in both hippocampus (HC) and anterior cingulate cortex (ACC) of individuals with major depressive episode(s) (MDE). This study investigated HC and ACC volume differences in currently depressed individuals (n = 150), individuals with a past lifetime MDE history (n = 79) and healthy controls (n = 287). Non-demented individuals were recruited from a cohort of community-dwelling older adults (ESPRIT study). T1-weighted magnetic resonance images and FreeSurfer Software (automated method) were used. Concerning HC, a manual method of measurement dividing HC into head, body, and tail was also used. General Linear Model was applied adjusting for covariates. Current depression was associated with lower left posterior HC volume, using manual measurement, in comparison to healthy status. However, when we slightly changed sub-group inclusion criteria, results did not survive to correction for multiple comparisons. The finding of lower left posterior HC volume in currently depressed individuals but not in those with a past MDE compared to healthy controls could be related to brain neuroplasticity. Additionally, our results may suggest manual measures to be more sensitive than automated methods.

Neuroimaging

Mood disorders

Depression

Biological markers

Brain imaging/neuroimaging

Details

Title: Subtitle: Smaller hippocampal volume in current but not in past depression in comparison to healthy controls: Minor evidence from an older adults sample
Creators: Ismaïl Bensassi - Neuropsychiatrie : Recherche Epidemiologique et Clinique
Jorge Lopez-Castroman - Inserm
Jerome J Maller - Monash Alfred Psychiatry Research centre
Chantal Meslin - Australian National University
Marilyn Wyart - Department of Adult Psychiatry, CHRU Nimes, Nimes, France
Karen Ritchie - Université de Montpellier
Philippe Courtet - Neuropsychiatrie : Recherche Epidemiologique et Clinique
Sylvaine Artero - Inserm
Raffaella Calati - Inserm
Resource Type: Journal article
Publication Details: Journal of psychiatric research, Vol.102, pp.159-167
DOI: 10.1016/j.jpsychires.2018.04.008
PMID: 29665490
NLM abbreviation: J Psychiatr Res
ISSN: 0022-3956
eISSN: 1879-1379
Language: English
Date published: 07/2018
Academic Unit: Radiology
Record Identifier: 9984848422702771

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