Journal article
Small‐vessel PCI outcomes in men, women, and minorities following platinum chromium everolimus‐eluting stents: Insights from the pooled PLATINUM Diversity and PROMUS Element Plus Post‐Approval studies
Catheterization and cardiovascular interventions, Vol.94(1), pp.82-90
07/01/2019
DOI: 10.1002/ccd.28071
PMID: 30666784
Abstract
Objective
We evaluated 1‐year outcomes after platinum chromium everolimus‐eluting stents (PtCr‐EES) in small versus non‐small coronary arteries within a large, diverse sample of men, women, and minorities.
Background
There exists limited outcomes data on the use of second‐generation drug‐eluting stent to treat small diameter coronary arteries.
Methods
We pooled patients from the PLATINUM Diversity and PROMUS Element Plus stent registries. Small‐vessel percutaneous coronary intervention (SV‐PCI) was defined as ≥1 target lesion with reference vessel diameter (RVD) ≤2.5 mm. Endpoints included major adverse cardiac event (MACE; death, myocardial infarction [MI] or target vessel revascularization [TVR]), target vessel failure (TVF; death related to the target vessel, target vessel MI or TVR) and definite/probable stent thrombosis (ST). Multivariable Cox regression was used to risk‐adjust outcomes.
Results
We included 4,155/4,182 (99%) patients with available RVD, of which 1,607 (39%) underwent small‐vessel PCI. SV‐PCI was not associated with increased MACE (adjHR 1.02; 95%CI 0.81–1.30) or TVF (adjHR 1.07; 95%CI 0.82–1.39). MI risk was lower in white men compared to women and minorities, both in the setting of SV‐PCI (adjHR 0.41; 95%CI 0.23–0.74 and adjHR 0.39; 95%CI 0.20–0.75, respectively) and for non‐SV‐PCI (adjHR 0.61; 95%CI 0.38–0.99 and adjHR 0.45; 95%CI 0.27–0.74, respectively). There was no significant interaction between RVD and sex or minority status for any endpoint.
Conclusion
In a large diverse contemporary PCI outcomes database, SV‐PCI with PtCr‐EES was not associated with increased MACE or TVR and did not account for the increased MI risk noted in women and minorities compared to white men.
Details
- Title: Subtitle
- Small‐vessel PCI outcomes in men, women, and minorities following platinum chromium everolimus‐eluting stents: Insights from the pooled PLATINUM Diversity and PROMUS Element Plus Post‐Approval studies
- Creators
- Paul Guedeney - Institut de Cardiologie, hôpital Pitié Salpêtrière (AP‐HP)Bimmer E. Claessen - Icahn School of Medicine at Mount SinaiRoxana Mehran - Icahn School of Medicine at Mount SinaiDavid E. Kandzari - Piedmont Atlanta HospitalMelissa Aquino - Icahn School of Medicine at Mount SinaiScott Davis - Arkansas Baptist CollegeLuis Tamis - University PhysiciansJohn C. Wang - MedStar Union Memorial HospitalIslam Othman - North Carolina Heart and Vascular Research, Raleigh, North Carolina.Osvaldo S. Gigliotti - Texas Heart InstituteAmir Haghighat - Cardiovascular Institute of Northwest FloridaSarabjeet Singh - Central Cardiology Medical ClinicMario Lopez - Charlotte Heart and Vascular Institute, Port Charlotte, Florida.Gregory Giugliano - Baystate Medical CenterPhillip A. Horwitz - University of IowaSabato Sorrentino - Icahn School of Medicine at Mount SinaiPaul Underwood - Boston ScientificDominic Allocco - Boston ScientificIan T. Meredith - Boston ScientificWayne Batchelor - Tallahassee Memorial HealthCare
- Resource Type
- Journal article
- Publication Details
- Catheterization and cardiovascular interventions, Vol.94(1), pp.82-90
- Publisher
- John Wiley & Sons, Inc
- DOI
- 10.1002/ccd.28071
- PMID
- 30666784
- ISSN
- 1522-1946
- eISSN
- 1522-726X
- Number of pages
- 9
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984359841702771
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