Smoking, Radiation Therapy, and Contralateral Breast Cancer Risk in Young Women

Anne S Reiner; Gordon P Watt; Esther M John; Charles F Lynch; Jennifer D Brooks; Lene Mellemkjær; John D Boice; Julia A Knight; Patrick Concannon; Susan A Smith; Xiaolin Liang; Meghan Woods; Roy Shore; Kathleen E Malone; Leslie Bernstein; Jonine L Bernstein; WECARE Study Collaborative Group

doi:10.1093/jnci/djab047

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Smoking, Radiation Therapy, and Contralateral Breast Cancer Risk in Young Women

Journal article

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Smoking, Radiation Therapy, and Contralateral Breast Cancer Risk in Young Women

Anne S Reiner, Gordon P Watt, Esther M John, Charles F Lynch, Jennifer D Brooks, Lene Mellemkjær, John D Boice, Julia A Knight, Patrick Concannon, Susan A Smith, …

JNCI : Journal of the National Cancer Institute, Vol.114(4), pp.631-634

03/29/2021

DOI: 10.1093/jnci/djab047

PMCID: PMC9002273

PMID: 33779721

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Abstract

Abstract Evidence is mounting that cigarette smoking contributes to second primary contralateral breast cancer (CBC) risk. Whether radiation therapy (RT) interacts with smoking to modify this risk is unknown. In this multicenter, individually matched, case-control study, we examined the association between RT, smoking, and CBC risk. The study included 1521 CBC cases and 2212 controls with unilateral breast cancer, all diagnosed with first invasive breast cancer between 1985 and 2008 aged younger than 55 years. Absorbed radiation doses to contralateral breast regions were estimated with thermoluminescent dosimeters in tissue-equivalent anthropomorphic phantoms, and smoking history was collected by interview. Rate ratios (RRs) and 95% confidence intervals (CIs) for CBC risk were estimated by multivariable conditional logistic regression. There was no interaction between any measure of smoking with RT to increase CBC risk (eg, the interaction of continuous RT dose with smoking at first breast cancer diagnosis [ever/never]: RR = 1.00, 95% CI = 0.89 to 1.14; continuous RT dose with years smoked: RR = 1.00, 95% CI = 0.99 to 1.01; and continuous RT dose with lifetime pack-years: RR = 1.00, 95% CI = 0.99 to 1.01). There was no evidence that RT further increased CBC risk in young women with first primary breast cancer who were current smokers or had smoking history.

Details

Title: Subtitle: Smoking, Radiation Therapy, and Contralateral Breast Cancer Risk in Young Women
Creators: Anne S Reiner - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Gordon P Watt - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Esther M John - Departments of Epidemiology & Population Health and Medicine, Stanford Cancer Institute, Stanford School of Medicine, Stanford, CA, USA
Charles F Lynch - Department of Epidemiology, The University of Iowa, Iowa City, IA, USA
Jennifer D Brooks - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Lene Mellemkjær - Unit of Breast Cancer Epidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark
John D Boice - Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Julia A Knight - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada
Patrick Concannon - Genetics Institute and Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA
Susan A Smith - Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Xiaolin Liang - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Meghan Woods - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Roy Shore - Department of Population Health, NYU School of Medicine, New York, NY, USA
Kathleen E Malone - Division of Public Health Sciences, Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle WA, USA
Leslie Bernstein - Department of Population Sciences, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA, USA
Jonine L Bernstein - Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
WECARE Study Collaborative Group
Resource Type: Journal article
Publication Details: JNCI : Journal of the National Cancer Institute, Vol.114(4), pp.631-634
DOI: 10.1093/jnci/djab047
PMID: 33779721
PMCID: PMC9002273
NLM abbreviation: J Natl Cancer Inst
ISSN: 0027-8874
eISSN: 1460-2105
Publisher: Oxford University Press
Grant note: DOI: 10.13039/100000002, name: US National Institutes of Health, award: CA129639, CA083178, CA097397, CA114236, CA008748
Language: English
Date published: 03/29/2021
Academic Unit: Epidemiology
Record Identifier: 9984214958602771

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