Journal article
Smoking and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis
Inflammatory bowel diseases, Vol.25(4), pp.672-678
03/14/2019
DOI: 10.1093/ibd/izy296
PMID: 30869794
Abstract
Background: The association between smoking and inflammatory bowel disease has long been recognized, but its role in the development of microscopic colitis is less well defined. This systematic review and meta-analysis was conducted with the aims to identify all available studies on the association between smoking and risk of microscopic colitis and to synthesize their results.
Methods: The MEDLINE and EMBASE databases were searched from inception to May 2018 for cohort studies and case-control studies that compared the risk of microscopic colitis among current/former smokers vs individuals who have never smoked. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were extracted from the included studies and pooled together using a random-effects model, generic inverse variance method of DerSimonian and Laird. Between-study heterogeneity was quantified using the Q statistic and I-2. Publication bias was assessed using funnel plots.
Results: Seven studies (2 cohort studies and 5 case-control studies) with 262,312 participants met the eligibility criteria and were included in the meta-analysis. Relative to never-smokers, current smokers had significantly increased odds of microscopic colitis, with a pooled OR of 2.99 (95% CI, 2.15-4.15; I-2, 64%). Former smokers also had significantly higher odds of microscopic colitis compared with never-smokers, with a pooled OR of 1.63 (95% CI, 1.37-1.94; I-2, 0%). Funnel plots were symmetric and did not provide suggestive evidence of publication bias for both analyses.
Conclusions: The current systematic review and meta-analysis found a significantly higher risk of microscopic colitis among current smokers compared with never-smokers. The risk attenuated among former smokers but remained significantly higher among never-smokers.
Details
- Title: Subtitle
- Smoking and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis
- Creators
- Veeravich Jaruvongvanich - King Chulalongkorn Memorial HospitalKittika Poonsombudlert - Mayo ClinicPatompong Ungprasert - Siriraj Hospital
- Resource Type
- Journal article
- Publication Details
- Inflammatory bowel diseases, Vol.25(4), pp.672-678
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/ibd/izy296
- PMID
- 30869794
- ISSN
- 1078-0998
- eISSN
- 1536-4844
- Number of pages
- 7
- Language
- English
- Date published
- 03/14/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984694747802771
Metrics
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