Smoking inhibits the frequency of bronchovascular bundle thickening in sarcoidosis

Alicia K Gerke; Edwin van Beek; Gary W Hunninghake

doi:10.1016/j.acra.2011.02.015

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Smoking inhibits the frequency of bronchovascular bundle thickening in sarcoidosis

Journal article

Peer reviewed

Smoking inhibits the frequency of bronchovascular bundle thickening in sarcoidosis

Alicia K Gerke, Edwin van Beek and Gary W Hunninghake

Academic radiology, Vol.18(7), pp.885-891

07/2011

DOI: 10.1016/j.acra.2011.02.015

PMCID: PMC3115466

PMID: 21530329

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https://www.research.ed.ac.uk/en/publications/443cd927-e33d-46ce-b09a-d2e72b8c97d0View

Open Access

Abstract

Smoking has been associated with decreased incidence and prevalence of sarcoidosis, but few studies have evaluated effects of smoking on clinical parameters of the disease. The objectives were to determine the association of smoking with radiographic patterns and to evaluate the associations of these smoking-related radiographic patterns on airflow obstruction in sarcoidosis. Clinical data and computed tomography (CT) scans of 124 patients with sarcoidosis were reviewed. CT scans were assessed for lymph nodes, nodules, bronchiectasis, bronchovascular bundle thickening, displaced hilum, fibrosis, ground glass, emphysema, pleural changes, and alveolar opacities. CT patterns were compared between patients with and without a history of smoking. The effect of smoking on the associations between radiographic patterns and airflow obstruction was assessed with multivariable analysis. Smokers had less frequency of bronchovascular bundle thickening than nonsmokers (11/38 subjects [29%] vs 50/86 subjects [58%], P = .003) and more emphysema (7/38 subjects [18%] vs 1/86 subjects [1%], P = .001). Patients who had bronchovascular bundle thickening were less likely to have ever smoked (11/61 subjects [18%] vs 27/63 subjects [43%], P = .003) or be current smokers (4/61 subjects [7%] vs 15/63 subjects [24%], P = .008). Age (P = .003) and bronchovascular bundle thickening (P = .02) were independent predictors of airflow obstruction. There were no differences in smoking history between patients with airflow obstruction versus those without (10/37 subjects [27%] vs 28/87 subjects [32%], P = .63). In patients with sarcoidosis, smoking is associated with decreased frequency of bronchovascular bundle thickening, an important clinical manifestation of the lung disease. Further, bronchovascular bundle thickening and age are the only independent predictors of airflow obstruction, and smoking does not confound these associations.

Comorbidity

Radiography

Risk Assessment - methods

Humans

Middle Aged

Risk Factors

Pulmonary Disease, Chronic Obstructive - epidemiology

Incidence

Young Adult

Sarcoidosis - epidemiology

Smoking - epidemiology

Adolescent

Adult

Female

Iowa - epidemiology

Pulmonary Disease, Chronic Obstructive - diagnostic imaging

Aged

Sarcoidosis - diagnostic imaging

Details

Title: Subtitle: Smoking inhibits the frequency of bronchovascular bundle thickening in sarcoidosis
Creators: Alicia K Gerke - Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA. alicia-gerke@uiowa.edu
Edwin van Beek
Gary W Hunninghake
Resource Type: Journal article
Publication Details: Academic radiology, Vol.18(7), pp.885-891
DOI: 10.1016/j.acra.2011.02.015
PMID: 21530329
PMCID: PMC3115466
NLM abbreviation: Acad Radiol
ISSN: 1076-6332
eISSN: 1878-4046
Grant note: KL2 RR024980-04 / NCRR NIH HHS G0701127 / Medical Research Council KL2 RR024980 / NCRR NIH HHS
Language: English
Date published: 07/2011
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984094584102771

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