Smoking status as a potential confound in the BOLD response of patients with schizophrenia

Leonard Leyba; Andrew R Mayer; Randy L Gollub; Nancy C Andreasen; Vincent P Clark

doi:10.1016/j.schres.2008.06.008

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Smoking status as a potential confound in the BOLD response of patients with schizophrenia

Journal article

Peer reviewed

Smoking status as a potential confound in the BOLD response of patients with schizophrenia

Leonard Leyba, Andrew R Mayer, Randy L Gollub, Nancy C Andreasen and Vincent P Clark

Schizophrenia research, Vol.104(1-3), pp.79-84

09/2008

DOI: 10.1016/j.schres.2008.06.008

PMCID: PMC2577169

PMID: 18684594

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Abstract

Functional magnetic resonance imaging (FMRI) studies comparing schizophrenia patients and controls may have been confounded by the vascular effects of heavier long-term cigarette use in patients. The blood oxygen level dependent (BOLD) response to a simple sensorimotor task was compared between schizophrenia patient with a smoking history (mean 17 pack years) and carefully matched patient non-smokers and control non-smokers. Group differences in activation magnitude and spatial extent were non-significant. Typical smoking histories in schizophrenia patients do not significantly confound FMRI results in simple sensorimotor tasks when patient demographics are carefully controlled.

Cigarette

Vascular disease

Schizophrenia

Functional magnetic resonance imaging

Atherosclerosis

Nicotine

Details

Title: Subtitle: Smoking status as a potential confound in the BOLD response of patients with schizophrenia
Creators: Leonard Leyba - The Mind Research Network, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, Albuquerque, NM 87131, United States
Andrew R Mayer - The Mind Research Network, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, Albuquerque, NM 87131, United States
Randy L Gollub - The Mind Research Network, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, Albuquerque, NM 87131, United States
Nancy C Andreasen - The Mind Research Network, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, Albuquerque, NM 87131, United States
Vincent P Clark - The Mind Research Network, Pete & Nancy Domenici Hall, 1101 Yale Blvd. NE, Albuquerque, NM 87131, United States
Resource Type: Journal article
Publication Details: Schizophrenia research, Vol.104(1-3), pp.79-84
DOI: 10.1016/j.schres.2008.06.008
PMID: 18684594
PMCID: PMC2577169
NLM abbreviation: Schizophr Res
ISSN: 0920-9964
eISSN: 1573-2509
Publisher: Elsevier B.V
Language: English
Date published: 09/2008
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003935202771

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