Journal article
Smooth Muscle Can Comprise the Sarcomatous Component of Gliosarcomas
Journal of neuropathology and experimental neurology, Vol.51(5), pp.493-498
09/1992
DOI: 10.1097/00005072-199209000-00003
PMID: 1381414
Abstract
The sarcomatous component of gliosarcomas is thought by many to originate from the vascular proliferation seen in glioblastoma multiforme and has, therefore, been assumed to be endothelial. Immunohistochemical staining of four gliosarcomas has led us to an alternate theory. Pathologically all four tumors were composed of at least two cell types; the first had a stellate, glial appearance and the second was either spindled or polygonal in shape. Polygonal cells were associated with glomeruloid vascular structures in some areas. Both components of each neoplasm were cytologically malignant. Glial fibrillary acidic protein and S-100 antibodies stained most of the glial-appearing cells and some of the spindled cells, but not the polygonal cells. Muscle specific a-actin and smooth muscle specific a-actin antibodies stained only the malignant spindled and polygonal cells and normal vascular smooth muscle. Ulex europaeus agglutinin I and anti-factor VIII/related antigen antibody stained only cells lining vascular lumina. The staining results suggest that the malignant mesenchymal component of these tumors is of smooth muscle origin. Having demonstrated elsewhere that glomeruloid vascular structures of glioblastoma multiforme contain smooth muscle cells, we propose here that gliosarcomas can represent one end of the spectrum of glioma-induced vascular smooth muscle proliferation.
Details
- Title: Subtitle
- Smooth Muscle Can Comprise the Sarcomatous Component of Gliosarcomas
- Creators
- Souheil Haddad - 1From the Division of Neurosurgery, The University of Iowa, Iowa City, Iowa 2From the Department of Pathology, The University of Iowa, Iowa City, IowaSteven MooreRobert SchelperJames Goeken
- Resource Type
- Journal article
- Publication Details
- Journal of neuropathology and experimental neurology, Vol.51(5), pp.493-498
- DOI
- 10.1097/00005072-199209000-00003
- PMID
- 1381414
- NLM abbreviation
- J Neuropathol Exp Neurol
- ISSN
- 0022-3069
- eISSN
- 1554-6578
- Publisher
- American Association of Neuropathologists, Inc
- Language
- English
- Date published
- 09/1992
- Academic Unit
- Pathology
- Record Identifier
- 9984047685802771
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