Journal article
Sociability and brain development in BALB/cJ and C57BL/6J mice
Behavioural brain research, Vol.228(2), pp.299-310
03/17/2012
DOI: 10.1016/j.bbr.2011.12.001
PMCID: PMC3474345
PMID: 22178318
Abstract
► C57BL/6J (B6) mice are more sociable than BALB/cJ mice before puberty. ► Sociability of B6 mice clusters according to litter membership. ► Larger perinatal litter size correlates with lower sociability in B6 mice. ► Larger male-to-female litter ratio correlates with lower sociability in B6 mice. ► Smaller brain size correlates with lower sociability in BALB/cJ mice.
Sociability—the tendency to seek social interaction—propels the development of social cognition and social skills, but is disrupted in autism spectrum disorders (ASD). BALB/cJ and C57BL/6J inbred mouse strains are useful models of low and high levels of juvenile sociability, respectively, but the neurobiological and developmental factors that account for the strains’ contrasting sociability levels are largely unknown. We hypothesized that BALB/cJ mice would show increasing sociability with age but that C57BL/6J mice would show high sociability throughout development. We also hypothesized that littermates would resemble one another in sociability more than non-littermates. Finally, we hypothesized that low sociability would be associated with low corpus callosum size and increased brain size in BALB/cJ mice. Separate cohorts of C57BL/6J and BALB/cJ mice were tested for sociability at 19-, 23-, 31-, 42-, or 70-days-of-age, and brain weights and mid-sagittal corpus callosum area were measured. BALB/cJ sociability increased with age, and a strain by age interaction in sociability between 31 and 42 days of age suggested strong effects of puberty on sociability development. Sociability scores clustered according to litter membership in both strains, and perinatal litter size and sex ratio were identified as factors that contributed to this clustering in C57BL/6J, but not BALB/cJ, litters. There was no association between corpus callosum size and sociability, but smaller brains were associated with lower sociability in BALB/cJ mice. The associations reported here will provide directions for future mechanistic studies of sociability development.
Details
- Title: Subtitle
- Sociability and brain development in BALB/cJ and C57BL/6J mice
- Creators
- Andrew H Fairless - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAHolly C Dow - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAArati Sadalge Kreibich - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAMatthew Torre - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAMariyam Kuruvilla - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAElliot Gordon - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAElizabeth A Morton - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAJunhao Tan - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAWade H Berrettini - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USAHongzhe Li - Statistical Genetics and Genomics Laboratory, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 215 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104-6021, USATed Abel - Department of Biology, University of Pennsylvania, 204G Lynch Laboratory, 433 South University Avenue, Philadelphia, PA 19104-6018, USAEdward S Brodkin - Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Translational Research Laboratory, 125 South 31st Street, Room 2220, Philadelphia, PA 19104-3403, USA
- Resource Type
- Journal article
- Publication Details
- Behavioural brain research, Vol.228(2), pp.299-310
- DOI
- 10.1016/j.bbr.2011.12.001
- PMID
- 22178318
- PMCID
- PMC3474345
- NLM abbreviation
- Behav Brain Res
- ISSN
- 0166-4328
- eISSN
- 1872-7549
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 03/17/2012
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065839102771
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