Journal article
Sociability development in mice with cell-specific deletion of the NMDA receptor NR1 subunit gene
Genes, brain and behavior, Vol.19(1), pp.e12624-n/a
01/2020
DOI: 10.1111/gbb.12624
PMCID: PMC7987227
PMID: 31721416
Abstract
Social affiliative behavior is an important component of everyday life in many species and is likely to be disrupted in disabling ways in various neurodevelopmental and neuropsychiatric disorders. Therefore, determining the mechanisms involved in these processes is crucial. A link between N-methyl-d-aspartate (NMDA) receptor function and social behaviors has been clearly established. The cell types in which NMDA receptors are critical for social affiliative behavior, however, remain unclear. Here, we use mice carrying a conditional allele of the NMDA R1 subunit to address this question. Mice bearing a floxed NMDAR1 (NR1) allele were crossed with transgenic calcium/calmodulin-dependent kinase IIα (CaMKIIα)-Cre mice or parvalbumin (PV)-Cre mice targeting postnatal excitatory forebrain or PV-expressing interneurons, respectively, and assessed using the three-chambered Social Approach Test. We found that deletion of NR1 in PV-positive interneurons had no effect on social sniffing, but deletion of NR1 in glutamatergic pyramidal cells resulted in a significant increase in social approach behavior, regardless of age or sex. Therefore, forebrain excitatory neurons expressing NR1 play an important role in regulating social affiliative behavior.
Details
- Title: Subtitle
- Sociability development in mice with cell-specific deletion of the NMDA receptor NR1 subunit gene
- Creators
- Sarah L Ferri - Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IowaAshley A Pallathra - Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaHyong Kim - Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaHolly C Dow - Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaPraachi Raje - Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaMary McMullen - Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaWarren B Bilker - Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PennsylvaniaSteven J Siegel - Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CaliforniaTed Abel - Department of Neuroscience and Pharmacology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IowaEdward S Brodkin - Center for Neurobiology and Behavior, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Genes, brain and behavior, Vol.19(1), pp.e12624-n/a
- DOI
- 10.1111/gbb.12624
- PMID
- 31721416
- PMCID
- PMC7987227
- NLM abbreviation
- Genes Brain Behav
- ISSN
- 1601-1848
- eISSN
- 1601-183X
- Publisher
- England
- Grant note
- 1P50MH096891 / NIMH NIH HHS P50 MH096891 / NIMH NIH HHS R01 AG062398 / NIA NIH HHS
- Language
- English
- Date published
- 01/2020
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070973502771
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