Journal article
Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants
Proceedings of the National Academy of Sciences - PNAS, Vol.105(21), pp.7506-7510
05/27/2008
DOI: 10.1073/pnas.0711127105
PMCID: PMC2396722
PMID: 18508973
Abstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived
Drosophila
mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.
Details
- Title: Subtitle
- Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants
- Creators
- Hongyu Ruan - Department of Biology, University of Iowa, Iowa City, IA 52242Chun-Fang Wu - Department of Biology, University of Iowa, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.105(21), pp.7506-7510
- DOI
- 10.1073/pnas.0711127105
- PMID
- 18508973
- PMCID
- PMC2396722
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Language
- English
- Date published
- 05/27/2008
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070556902771
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