Journal article
Social well-being is associated with less pro-inflammatory and pro-metastatic leukocyte gene expression in women after surgery for breast cancer
Breast cancer research and treatment, Vol.165(1), pp.169-180
08/2017
DOI: 10.1007/s10549-017-4316-3
PMCID: PMC5528864
PMID: 28560656
Abstract
Satisfaction with social resources, or “social well-being,” relates to better adaptation and longer survival after breast cancer diagnosis. Biobehavioral mechanisms linking social well-being (SWB) to mental and physical health may involve inflammatory signaling. We tested whether reports of greater SWB were associated with lower levels of pro-inflammatory and pro-metastatic leukocyte gene expression after surgery for non-metastatic breast cancer.Women (N = 50) diagnosed with non-metastatic (0–III) breast cancer were enrolled 2–8 weeks after surgery. SWB was assessed with the social/family well-being subscale of the FACT-B. Leukocyte gene expression for specific pro-inflammatory (cytokines, chemokines, and COX-2) and pro-metastatic genes (e.g., MMP9) was derived from microarray analysis.Multiple regression analyses controlling for age, stage of disease, days since surgery, education, and body mass index (BMI) found higher levels of SWB related to less leukocyte pro-inflammatory and pro-metastatic gene expression (p < 0.05). Emotional well-being, physical well-being, and functional well-being did not relate to leukocyte gene expression (p > 0.05). Greater SWB remained significantly associated with less leukocyte pro-inflammatory and pro-metastatic gene expression after controlling for depressive symptoms.Results have implications for understanding mechanisms linking social resources to health-relevant biological processes in breast cancer patients undergoing primary treatment.Clinical Trial Registration Number: NCT01422551
Details
- Title: Subtitle
- Social well-being is associated with less pro-inflammatory and pro-metastatic leukocyte gene expression in women after surgery for breast cancer
- Creators
- Devika Jutagir - Department of Psychology University of Miami 5665 Ponce De Leon Blvd. Coral Gables FL 33146 USABonnie Blomberg - Department of Microbiology and Immunology University of Miami Miller School of Medicine 1600 NW 10th Ave., RMSB 3146A Miami FL 33136 USACharles Carver - Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine 1475 NW 12th Ave. Miami FL 33136 USASuzanne Lechner - Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine 1475 NW 12th Ave. Miami FL 33136 USAKiara Timpano - Department of Psychology University of Miami 5665 Ponce De Leon Blvd. Coral Gables FL 33146 USALaura Bouchard - Department of Psychology University of Miami 5665 Ponce De Leon Blvd. Coral Gables FL 33146 USALisa Gudenkauf - Department of Psychology University of Miami 5665 Ponce De Leon Blvd. Coral Gables FL 33146 USAJamie Jacobs - The Center for Psychiatric Oncology and Behavioral Sciences Massachusetts General Hospital Cancer Center 55 Fruit Street, Yawkey Center for Outpatient Care, Suite 10B Boston MA 02116 USAAlain Diaz - Department of Microbiology and Immunology University of Miami Miller School of Medicine 1600 NW 10th Ave., RMSB 3146A Miami FL 33136 USASusan Lutgendorf - Department of Psychological and Brain Sciences University of Iowa E11 Seashore Hall Iowa City IA 52242 USASteve Cole - Department of Medicine UCLA School of Medicine 11-934 Factor Building Los Angeles CA 90095 USAAaron Heller - Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine 1475 NW 12th Ave. Miami FL 33136 USAMichael Antoni - Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine 1475 NW 12th Ave. Miami FL 33136 USA
- Resource Type
- Journal article
- Publication Details
- Breast cancer research and treatment, Vol.165(1), pp.169-180
- DOI
- 10.1007/s10549-017-4316-3
- PMID
- 28560656
- PMCID
- PMC5528864
- NLM abbreviation
- Breast Cancer Res Treat
- ISSN
- 0167-6806
- eISSN
- 1573-7217
- Publisher
- Springer US; New York
- Grant note
- R01-CA-064710 / National Cancer Institute (http://dx.doi.org/10.13039/100000054) Sylvester Comprehensive Cancer Center
- Language
- English
- Date published
- 08/2017
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984002454202771
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