Sociodemographic and hispanic acculturation factors and isolated anotia/microtia

Adrienne T Hoyt; Mark A Canfield; Gary M Shaw; Dorothy K Waller; Kara N D Polen; Tunu Ramadhani; Marlene T Anderka; Angela E Scheuerle; National Birth Defects Prevention Study

doi:10.1002/bdra.23282

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Sociodemographic and hispanic acculturation factors and isolated anotia/microtia

Journal article

Peer reviewed

Sociodemographic and hispanic acculturation factors and isolated anotia/microtia

Adrienne T Hoyt, Mark A Canfield, Gary M Shaw, Dorothy K Waller, Kara N D Polen, Tunu Ramadhani, Marlene T Anderka, Angela E Scheuerle and National Birth Defects Prevention Study

Birth defects research. A Clinical and molecular teratology, Vol.100(11), pp.852-862

11/2014

DOI: 10.1002/bdra.23282

PMCID: PMC4706758

PMID: 25074828

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Abstract

It has been observed in several studies that infants with anotia/microtia are more common among Hispanics compared with other racial/ethnic groups. We examined the association between selected Hispanic ethnicity and acculturation factors and anotia/microtia in the National Birth Defects Prevention Study. We examined data from mothers of 351 infants with isolated anotia/microtia and 8435 unaffected infants from the National Birth Defects Prevention Study with an expected delivery date from 1997 to 2007. Sociodemographic, maternal, and acculturation factors (e.g., age, maternal education, household income, body mass index, gestational diabetes, folic acid, smoking, alcohol intake, study center, parental birthplace, and years lived in the United States, maternal language) were assessed as overall risk factors and also as risk factors among subgroups of Hispanics (United States- and foreign-born) versus non-Hispanic whites. Compared with non-Hispanic whites, both United States- and foreign-born Hispanic mothers demonstrated substantially higher odds of delivering infants with anotia/microtia across nearly all strata of sociodemographic and other maternal factors (adjusted odds ratios range: 2.1-11.9). The odds of anotia/microtia was particularly elevated among Hispanic mothers who emigrated from Mexico after age five (adjusted odds ratios = 4.88; 95% confidence interval = 2.93-8.11) or who conducted the interview in Spanish (adjusted odds ratios = 4.97; 95% confidence interval = 3.00-8.24). We observed that certain sociodemographic and acculturation factors are associated with higher risks of anotia/microtia among offspring of Hispanic mothers.

Acculturation

Adult

Age Factors

Alcohol Drinking - ethnology

Congenital Microtia - economics

Congenital Microtia - epidemiology

Congenital Microtia - ethnology

Congenital Microtia - pathology

Ear Auricle - abnormalities

Educational Status

European Continental Ancestry Group

Female

Folic Acid - administration & dosage

Health Care Costs - statistics & numerical data

Hispanic Americans

Humans

Infant

Male

Mothers

Odds Ratio

Prevalence

Risk

Social Class

United States - epidemiology

Details

Title: Subtitle: Sociodemographic and hispanic acculturation factors and isolated anotia/microtia
Creators: Adrienne T Hoyt - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas
Mark A Canfield
Gary M Shaw
Dorothy K Waller
Kara N D Polen
Tunu Ramadhani
Marlene T Anderka
Angela E Scheuerle
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.100(11), pp.852-862
DOI: 10.1002/bdra.23282
PMID: 25074828
PMCID: PMC4706758
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley
Grant note: U01 DD000494 / NCBDD CDC HHS CC999999 / Intramural CDC HHS U01DD000494 / NCBDD CDC HHS
Language: English
Date published: 11/2014
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214697902771

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