Socioeconomic Status in Relation to Selected Birth Defects in a Large Multicentered US Case-Control Study

J Yang; S. L Carmichael; M Canfield; J Song; G. M Shaw; National Birth Defects Prevention Study

doi:10.1093/aje/kwm283

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Socioeconomic Status in Relation to Selected Birth Defects in a Large Multicentered US Case-Control Study

Journal article

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Peer reviewed

Socioeconomic Status in Relation to Selected Birth Defects in a Large Multicentered US Case-Control Study

J Yang, S. L Carmichael, M Canfield, J Song, G. M Shaw and National Birth Defects Prevention Study

American journal of epidemiology, Vol.167(2), pp.145-154

01/15/2008

DOI: 10.1093/aje/kwm283

PMID: 17947220

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Abstract

This study examined individual and household socioeconomic status (SES) in relation to phenotypes of neural tube defects, orafacial clefts, and conotruncal heart defects using data from the National Birth Defects Prevention Study with 2,551 nonmalformed liveborn controls and 1,841 cases delivered in 1997-2000. The individual SES was measured by maternal and paternal education, occupation, and household income. All individual SES measures were combined to create a household SES index. Elevated risks were found for maternal low education in association with anencephaly and dextrotransposition of the great arteries (dTGA) (adjusted odds ratios (AORs) ≥ 1.4); paternal low education in association with anencephaly, cleft palate, tetralogy of Fallot (TOF), and dTGA (AORs ≥ 1.4); low household income in association with TOF (AOR = 1.4, 95% confidence interval (CI): 0.8, 2.5); maternal operator/laborer occupation in association with cleft palate, TOF, and dTGA (AORs ≥ 1.4); paternal operator/laborer occupation in association with spina bifida (AOR = 1.4, 95% CI: 1.0, 2.0); and either parent's unemployment in association with dTGA (AOR ≥ 1.4). Subjects with the lowest household SES index had the greatest risks of all selected birth defects except TOF. This study reveals consistently increased risks of selected birth defects in association with household SES index but not individual SES measures.

cleft lip

cleft palate

heart defects

neural tube defects

congenital

social class

Details

Title: Subtitle: Socioeconomic Status in Relation to Selected Birth Defects in a Large Multicentered US Case-Control Study
Creators: J Yang - 1California Research Division, March of Dimes Foundation, Oakland, CA
S. L Carmichael - 1California Research Division, March of Dimes Foundation, Oakland, CA
M Canfield - 2Birth Defects and Epidemiology Branch, Texas Department of State Health Services, Austin, TX
J Song - 1California Research Division, March of Dimes Foundation, Oakland, CA
G. M Shaw - 1California Research Division, March of Dimes Foundation, Oakland, CA
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.167(2), pp.145-154
DOI: 10.1093/aje/kwm283
PMID: 17947220
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: Oxford University Press
Language: English
Date published: 01/15/2008
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214951902771

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