Socioeconomic status is independently associated with overall survival in patients with multiple myeloma

Mark A Fiala; Joseph D Finney; Jingxia Liu; Keith E Stockerl-Goldstein; Michael H Tomasson; Ravi Vij; Tanya M Wildes

doi:10.3109/10428194.2015.1011156

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Socioeconomic status is independently associated with overall survival in patients with multiple myeloma

Journal article

Peer reviewed

Socioeconomic status is independently associated with overall survival in patients with multiple myeloma

Mark A Fiala, Joseph D Finney, Jingxia Liu, Keith E Stockerl-Goldstein, Michael H Tomasson, Ravi Vij and Tanya M Wildes

Leukemia & lymphoma, Vol.56(9), pp.2643-2649

09/02/2015

DOI: 10.3109/10428194.2015.1011156

PMCID: PMC4831207

PMID: 25651424

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Abstract

Population-based studies suggest that black patients with multiple myeloma (MM) have a higher mortality rate than white patients. However, other studies suggest that this disparity is related to socioeconomic status (SES) rather than race. To provide clarity on this topic, we reviewed 562 patients diagnosed with MM at our institution. Patients with high SES had a median overall survival (OS) of 62.8 months (95% confidence interval [CI] 43.1-82.6 months), compared to 53.7 months (45.2-62.3 months) and 48.6 months (40.4-56.8 months) for middle and low SES, respectively (p = 0.015). After controlling for race, age, year of diagnosis, severity of comorbidities, stem cell transplant utilization and insurance provider, patients with low SES had a 54% increase in mortality rate relative to patients with high SES. To support our findings, we performed a similar analysis of 45,505 patients with MM from the Surveillance, Epidemiology and End Results-18 (SEER) database. Low SES is independently associated with poorer OS in MM.

race

cancer health disparities

socioeconomic status

Multiple myeloma

Details

Title: Subtitle: Socioeconomic status is independently associated with overall survival in patients with multiple myeloma
Creators: Mark A Fiala - Division of Oncology, Washington University School of Medicine
Joseph D Finney - Division of Oncology, Washington University School of Medicine
Jingxia Liu - Division of Biostatistics, Department of Medicine, Washington University School of Medicine
Keith E Stockerl-Goldstein - Division of Oncology, Washington University School of Medicine
Michael H Tomasson - Division of Oncology, Washington University School of Medicine
Ravi Vij - Division of Oncology, Washington University School of Medicine
Tanya M Wildes - Division of Oncology, Washington University School of Medicine
Resource Type: Journal article
Publication Details: Leukemia & lymphoma, Vol.56(9), pp.2643-2649
DOI: 10.3109/10428194.2015.1011156
PMID: 25651424
PMCID: PMC4831207
NLM abbreviation: Leuk Lymphoma
ISSN: 1042-8194
eISSN: 1029-2403
Publisher: Taylor & Francis
Language: English
Date published: 09/02/2015
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984094557402771

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