Journal article
Soft tissue nasal asymmetry as an indicator of orofacial cleft predisposition
American journal of medical genetics. Part A, Vol.176(6), pp.1296-1303
06/2018
DOI: 10.1002/ajmg.a.38688
PMCID: PMC5992056
PMID: 29663709
Abstract
The biological relatives of offspring with nonsyndromic orofacial clefts have been shown to exhibit distinctive facial features, including excess asymmetry, which are hypothesized to indicate the presence of genetic risk factors. The significance of excess soft tissue nasal asymmetry in at-risk relatives is unclear and was examined in the present study. Our sample included 164 unaffected parents from families with a history of orofacial clefting and 243 adult controls. Geometric morphometric methods were used to analyze the coordinates of 15 nasal landmarks collected from three-dimensional facial surface images. Following generalized Procrustes analysis, Procrustes ANOVA and MANOVA tests were applied to determine the type and magnitude of nasal asymmetry present in each group. Group differences in mean nasal asymmetry were also assessed via permutation testing. We found that nasal asymmetry in both parents and controls was directional in nature, although the magnitude of the asymmetry was greater in parents. This was confirmed with permutation testing, where the mean nasal asymmetry was significantly different (p < .0001) between parents and controls. The asymmetry was greatest for midline structures and the nostrils. When subsets of parents were subsequently analyzed and compared (parents with bilateral vs. unilateral offspring; parents with left vs. right unilateral offspring), each group showed a similar pattern of asymmetry and could not be distinguished statistically. Thus, the side of the unilateral cleft (right vs. left) in offspring was not associated with the direction of the nasal asymmetry in parents.
Details
- Title: Subtitle
- Soft tissue nasal asymmetry as an indicator of orofacial cleft predisposition
- Creators
- Charles Zhang - Department of Anthropology, University of Pittsburgh, Pittsburgh, PennsylvaniaSteven F Miller - Department of Anatomy, Midwestern University, Downers Grove, IllinoisJasmien Roosenboom - Center for Craniofacial and Dental Genetics, Department of Oral Biology, University of Pittsburgh, Pittsburgh, PennsylvaniaGeorge L Wehby - Department of Health Management and Policy, University of Iowa, Iowa City, IowaLina M Moreno Uribe - Department of Orthodontics, University of Iowa, Iowa City, IowaJacqueline T Hecht - Department of Pediatrics, University of Texas McGovern Medical Center, Houston, TexasFrederic W B Deleyiannis - Department of Pediatric Plastic Surgery, Children's Hospital of Colorado, Aurora, ColoradoKaare Christensen - Institute of Public Health, University of Southern Denmark, Odense, DenmarkMary L Marazita - Department of Human Genetics, University of Pittsburgh, Pittsburgh, PennsylvaniaSeth M Weinberg - Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part A, Vol.176(6), pp.1296-1303
- DOI
- 10.1002/ajmg.a.38688
- PMID
- 29663709
- PMCID
- PMC5992056
- NLM abbreviation
- Am J Med Genet A
- ISSN
- 1552-4825
- eISSN
- 1552-4833
- Publisher
- United States
- Grant note
- R01 DD000295 / NCBDD CDC HHS\nU01 DE020078 / NIDCR NIH HHS\nR01 DE016148 / NIDCR NIH HHS
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Preventive and Community Dentistry; Orthodontics; Health Management and Policy; Economics; Craniofacial Anomalies Research Center; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9984065994902771
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