Solanapyrone analogues from a Hawaiian fungicolous fungus

Lori E Schmidt; James B Gloer; Donald T Wicklow

doi:10.1021/np070251m

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Solanapyrone analogues from a Hawaiian fungicolous fungus

Journal article

Peer reviewed

Solanapyrone analogues from a Hawaiian fungicolous fungus

Lori E Schmidt, James B Gloer and Donald T Wicklow

Journal of natural products (Washington, D.C.), Vol.70(8), pp.1317-1320

08/2007

DOI: 10.1021/np070251m

PMCID: PMC2532753

PMID: 17663585

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https://www.ncbi.nlm.nih.gov/pmc/articles/2532753View

Open Access

Abstract

Four new solanapyrone analogues (solanapyrones J-M; 1-4) have been isolated from an unidentified fungicolous fungus collected in Hawaii. The structures and relative configurations of these compounds were determined by analysis of 1D NMR, 2D NMR, and MS data. Solanapyrone J (1) showed antifungal activity against Aspergillus flavus and Fusarium verticillioides, while both 1 and 2 showed activity against Staphylococcus aureus and Candida albicans.

Anti-Bacterial Agents - chemistry

Anti-Bacterial Agents - isolation & purification

Anti-Bacterial Agents - pharmacology

Antifungal Agents - chemistry

Antifungal Agents - isolation & purification

Antifungal Agents - pharmacology

Aspergillus flavus - drug effects

Candida albicans - drug effects

Fungi - chemistry

Fusarium - drug effects

Hawaii

Microbial Sensitivity Tests

Molecular Structure

Nuclear Magnetic Resonance, Biomolecular

Pyrones - chemistry

Pyrones - isolation & purification

Pyrones - pharmacology

Staphylococcus aureus - drug effects

Details

Title: Subtitle: Solanapyrone analogues from a Hawaiian fungicolous fungus
Creators: Lori E Schmidt - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
James B Gloer
Donald T Wicklow
Resource Type: Journal article
Publication Details: Journal of natural products (Washington, D.C.), Vol.70(8), pp.1317-1320
DOI: 10.1021/np070251m
PMID: 17663585
PMCID: PMC2532753
NLM abbreviation: J Nat Prod
ISSN: 0163-3864
eISSN: 1520-6025
Grant note: P41RR0954 / NCRR NIH HHS R01 GM060600-07 / NIGMS NIH HHS GM 60600 / NIGMS NIH HHS R01 GM060600-04 / NIGMS NIH HHS R01 GM060600 / NIGMS NIH HHS R01 GM060600-06 / NIGMS NIH HHS R01 GM060600-05 / NIGMS NIH HHS P41 RR000954 / NCRR NIH HHS
Language: English
Date published: 08/2007
Academic Unit: Chemistry
Record Identifier: 9984216684002771

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