Journal article
Solid phase synthesis of tyrosine-containing histone fragments
Tetrahedron, Vol.39(19), pp.3185-3188
1983
DOI: 10.1016/S0040-4020(01)91564-9
Abstract
The solid phase synthesis of Ac-Val-Val-Tyr-Ala-Leu-OH (
1), Ac-Glu-Ala-Tyr-Leu-Val-OH (
2) and Ac-Leu-Tyr-Gly-Phe-Gly-Gly-OH (
3), segments 86–90 of histone
H4, 97–101 of histone
H3 and 97–102 of histone
H4, respectively, is described using chloromethylresin and chloromethyl-Pab-resin as solid supports. In the synthesis of peptides
2 and
3 using 2,6-diclorobenzyl ether as tyrosine side chain protection, 7% and 8% of the 3-dichlorobenzyltyrosine-rearranged peptide could be isolated by Bio-Gel
P-2 or diethylaminoethylcellulose chromatography. Alternative use of cyclohexyl ether as tyrosine protection has been explored with satisfactory results.
Details
- Title: Subtitle
- Solid phase synthesis of tyrosine-containing histone fragments
- Creators
- Ernest Giralt - Universitat de BarcelonaDavid Andreu - Universitat de BarcelonaPere Miro - Universitat de BarcelonaEnrique Pedroso - Universitat de Barcelona
- Resource Type
- Journal article
- Publication Details
- Tetrahedron, Vol.39(19), pp.3185-3188
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0040-4020(01)91564-9
- ISSN
- 0040-4020
- eISSN
- 1464-5416
- Language
- English
- Date published
- 1983
- Academic Unit
- Chemistry
- Record Identifier
- 9984618496402771
Metrics
1 Record Views