Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose

Naresh C Gupta; Albert R Frank; Naresh A Dewan; L S Redepenning; M L Rothberg; James A Mailliard; J J Phalen; John J Sunderland; Mathis P Frick

doi:10.1148/radiology.184.2.1620844

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Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose

Journal article

Peer reviewed

Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose

Naresh C Gupta, Albert R Frank, Naresh A Dewan, L S Redepenning, M L Rothberg, James A Mailliard, J J Phalen, John J Sunderland and Mathis P Frick

Radiology, Vol.184(2), pp.441-444

08/1992

DOI: 10.1148/radiology.184.2.1620844

PMID: 1620844

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Abstract

It is estimated that nearly one-third of solitary pulmonary nodules (SPNs) may represent bronchogenic carcinoma. The noninvasive imaging methods used currently (ie, plain radiography, computed tomography) are not reliable for accurate detection of malignancy in most SPNs. The authors prospectively evaluated use of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) for identification of malignancy in 20 patients with noncalcific, radiographically indeterminate SPNs. PET-FDG imaging demonstrated focal hypermetabolism in 13 biopsy-proved malignant nodules, whereas no increased FDG uptake was seen in the seven benign SPNs. Semiquantitative analysis with computation of differential uptake ratios also helped clearly differentiate benign nodules (mean +/- standard deviation, 0.56 +/- 0.27) from malignant nodules (mean +/- standard deviation, 5.63 +/- 2.38) (P less than .001). Thus, PET-FDG imaging may be a potentially useful noninvasive technique for accurate differentiation of benign and malignant SPNs that are radiographically indeterminate.

Solitary Pulmonary Nodule - epidemiology

Prospective Studies

Humans

Middle Aged

Male

Deoxyglucose - analogs & derivatives

Solitary Pulmonary Nodule - diagnostic imaging

Lung Neoplasms - epidemiology

Aged, 80 and over

Adult

Female

Fluorodeoxyglucose F18

Lung Neoplasms - diagnostic imaging

Aged

Tomography, Emission-Computed

Details

Title: Subtitle: Solitary pulmonary nodules: detection of malignancy with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose
Creators: Naresh C Gupta - Department of Radiology, Creighton University Medical Center, Omaha, NE 68131
Albert R Frank
Naresh A Dewan
L S Redepenning
M L Rothberg
James A Mailliard
J J Phalen
John J Sunderland
Mathis P Frick
Resource Type: Journal article
Publication Details: Radiology, Vol.184(2), pp.441-444
Publisher: United States
DOI: 10.1148/radiology.184.2.1620844
PMID: 1620844
ISSN: 0033-8419
eISSN: 1527-1315
Language: English
Date published: 08/1992
Academic Unit: Radiology; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984047683202771

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