Journal article
Soluble HLA-G Molecules Induce Apoptosis in Natural Killer Cells
American journal of reproductive immunology (1989), Vol.56(1), pp.68-76
Submitted December 19, 2005; accepted April 3, 2006
07/2006
DOI: 10.1111/j.1600-0897.2006.00395.x
PMID: 16792533
Abstract
Membrane-bound human leukocyte antigen-G (HLA-G) molecules are primarily expressed by cytotrophoblasts of the fetus. They are thought to protect the fetus from immunologic attack by the maternal immune system and have recently been associated with transplantation graft acceptance. In addition, soluble HLA-G molecules (sHLA-G) have been shown to play a role in the success of pregnancies, but are upregulated in certain cancers. However, the exact mechanism for this regulation has remained elusive. The aim of this study was to examine the mechanism by which sHLA-G interact with natural killer (NK) cells in vitro. sHLA-G effectively blocked NK lysis of target cells via fracticide killing of NK cells by apoptosis. These studies support the protective role of sHLA-G in immunologic reactions by interacting with NK cells, thus providing a regulatory function.
Details
- Title: Subtitle
- Soluble HLA-G Molecules Induce Apoptosis in Natural Killer Cells
- Creators
- Amy Lindaman - Department of Internal Medicine, University of Iowa Hospital and Clinics & VA Medical Center Iowa City, Iowa City, IA, USAAmy Dowden - Department of Internal Medicine, University of Iowa Hospital and Clinics & VA Medical Center Iowa City, Iowa City, IA, USANicholas Zavazava - Department of Internal Medicine, University of Iowa Hospital and Clinics & VA Medical Center Iowa City, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- American journal of reproductive immunology (1989), Vol.56(1), pp.68-76
- Edition
- Submitted December 19, 2005; accepted April 3, 2006
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1111/j.1600-0897.2006.00395.x
- PMID
- 16792533
- ISSN
- 1046-7408
- eISSN
- 1600-0897
- Number of pages
- 9
- Language
- English
- Date published
- 07/2006
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Stead Family Department of Pediatrics; Immunology; Internal Medicine
- Record Identifier
- 9984093455602771
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