Journal article
Soluble Inflammatory Markers and Risk of Incident Fractures in Older Adults: The Cardiovascular Health Study
Journal of bone and mineral research, Vol.33(2), pp.221-228
02/2018
DOI: 10.1002/jbmr.3301
PMCID: PMC5809254
PMID: 28976598
Abstract
ABSTRACT
Several in vitro and animal studies have showed that inflammatory markers play a role in bone remodeling and pathogenesis of osteoporosis. Additionally, some human longitudinal studies showed suggestive associations between elevated inflammatory markers and increased risk of nontraumatic fractures. We examined several inflammatory markers and multiple fracture types in a single study of older individuals with extensive follow‐up. We assessed the association of four inflammatory markers with the risk of incident hip fractures among 5265 participants of the Cardiovascular Health Study (CHS) and a composite endpoint of incident fractures of the hip, pelvis, humerus, or proximal forearm in 4477 participants. Among CHS participants followed between 1992 and 2009, we observed 480 incident hip fractures during a median follow‐up of 11 years. In the composite fracture analysis cohort of 4477 participants, we observed 711 fractures during a median follow‐up of 7 years. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for hip fracture associated with doubling of IL‐6 were HR 1.15 (95% CI, 1.02 to 1.30) overall and HR 1.17 (95% CI, 1.01 to 1.35) in women. We also observed a positive association between each unit increase in white blood cell (WBC) count and risk of hip fracture: HR 1.04 (95% CI, 1.01 to 1.06) overall and HR 1.06 (95% CI, 0.95 to 1.20) in women. We observed no significant associations between any of the four inflammatory markers and a composite fracture endpoint. Our findings suggest that chronic inflammatory and immune processes may be related to higher rates of incident hip fractures. © 2017 American Society for Bone and Mineral Research.
Details
- Title: Subtitle
- Soluble Inflammatory Markers and Risk of Incident Fractures in Older Adults: The Cardiovascular Health Study
- Creators
- Danijela Stojanović - US Food and Drug AdministrationDiana Jalal - University of Colorado School of MedicinePetra Bůžková - University of WashingtonKenneth J Mukamal - BostonSusan R Heckbert - University of WashingtonBruce M Psaty - University of WashingtonHoward A Fink - University of MinnesotaJane A Cauley - University of PittsburghErin Wallace - SeattleLesley H Curtis - Duke University School of MedicineCalvin Hirsch - University of CaliforniaMatthew Budoff - Harbor–University of CaliforniaDong Li - Los Angeles Biomedical Research InstituteRebekah Young - University of WashingtonJoseph AC Delaney - University of Washington
- Resource Type
- Journal article
- Publication Details
- Journal of bone and mineral research, Vol.33(2), pp.221-228
- DOI
- 10.1002/jbmr.3301
- PMID
- 28976598
- PMCID
- PMC5809254
- ISSN
- 0884-0431
- eISSN
- 1523-4681
- Number of pages
- 8
- Grant note
- R01AG023629 from the National Institute on Aging
- Language
- English
- Date published
- 02/2018
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094596202771
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