Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients

Jordan E Krull; Kerstin Wenzl; Keenan T Hartert; Michelle K Manske; Vivekananda Sarangi; Matthew J Maurer; Melissa C Larson; Grzegorz S Nowakowski; Stephen M Ansell; Ellen McPhail; Thomas M Habermann; Brian K Link; Rebecca L King; James R Cerhan; Anne J Novak

doi:10.1038/s41408-020-00382-3

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Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients

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Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients

Jordan E Krull, Kerstin Wenzl, Keenan T Hartert, Michelle K Manske, Vivekananda Sarangi, Matthew J Maurer, Melissa C Larson, Grzegorz S Nowakowski, Stephen M Ansell, Ellen McPhail, …

Blood cancer journal (New York), Vol.10(11), pp.117-117

11/09/2020

DOI: 10.1038/s41408-020-00382-3

PMCID: PMC7652824

PMID: 33168821

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Abstract

Double/triple hit lymphoma (DH/TH), known as high-grade B-cell lymphoma (HGBL), is an aggressive diffuse large B cell lymphoma (DLBCL), defined as having concurrent MYC, BCL2, and/or BCL6 gene rearrangements. While gene rearrangements represent significant genetic events in cancer, copy number alterations (CNAs) also play an important role, and their contributions to rearrangements have yet to be fully elucidated. Using FISH and high-resolution CNA data, we defined the landscape of concurrent gene rearrangements and copy gains in MYC, BCL2, and BCL6, in a cohort of 479 newly diagnosed DLBCL. We also show that concurrent translocations and copy number alterations, in combinations similar to DH/TH, identify a unique subset of DLBCL, alternative DH/TH, that have survival outcomes similar to DH/TH DLBCL patients.

Female

Gene Dosage

Humans

Lymphoma, Large B-Cell, Diffuse - genetics

Lymphoma, Large B-Cell, Diffuse - metabolism

Male

Middle Aged

Proto-Oncogene Proteins c-bcl-2 - genetics

Proto-Oncogene Proteins c-bcl-2 - metabolism

Proto-Oncogene Proteins c-bcl-6 - genetics

Proto-Oncogene Proteins c-bcl-6 - metabolism

Proto-Oncogene Proteins c-myc - genetics

Proto-Oncogene Proteins c-myc - metabolism

Details

Title: Subtitle: Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
Creators: Jordan E Krull - Mayo Clinic
Kerstin Wenzl - Mayo Clinic
Keenan T Hartert - Mayo Clinic
Michelle K Manske - Mayo Clinic
Vivekananda Sarangi - Mayo Clinic
Matthew J Maurer - Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
Melissa C Larson - Mayo Clinic
Grzegorz S Nowakowski - Mayo Clinic
Stephen M Ansell - Mayo Clinic
Ellen McPhail - Division of Hematopathology, Mayo Clinic, Rochester, USA
Thomas M Habermann - Mayo Clinic
Brian K Link - University of Iowa
Rebecca L King - Mayo Clinic
James R Cerhan - Mayo Clinic
Anne J Novak - Division of Hematology, Mayo Clinic, Rochester, USA,
Resource Type: Journal article
Publication Details: Blood cancer journal (New York), Vol.10(11), pp.117-117
DOI: 10.1038/s41408-020-00382-3
PMID: 33168821
PMCID: PMC7652824
NLM abbreviation: Blood Cancer J
ISSN: 2044-5385
eISSN: 2044-5385
Grant note: U01 CA195568 / NCI NIH HHS T32 AI007425 / NIAID NIH HHS R01 CA212162 / NCI NIH HHS P30 CA086862 / NCI NIH HHS P50 CA097274 / NCI NIH HHS
Language: English
Date published: 11/09/2020
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
Record Identifier: 9984359883302771

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